Galactoside 2-alpha-L-fucosyltransferase explained

galactoside 2-alpha-L-fucosyltransferase
Ec Number:	2.4.1.69
Cas Number:	56093-23-3
Go Code:	0008107

In enzymology, a galactoside 2-alpha-L-fucosyltransferase is an enzyme that catalyzes the chemical reaction

GDP-beta-L-fucose + beta-D-galactosyl-R

\rightleftharpoons GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R

Thus, the two substrates of this enzyme are GDP-beta-L-fucose and beta-D-galactosyl-R, whereas its two products are GDP and alpha-L-fucosyl-1,2-beta-D-galactosyl-R.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. This enzyme participates in 4 metabolic pathways: glycosphingolipid biosynthesis - lactoseries, glycosphingolipid biosynthesis - neo-lactoseries, glycosphingolipid biosynthesis - globoseries, and glycan structures - biosynthesis 2.

Nomenclature

The systematic name of this enzyme class is:

• GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase

Other names in common use include:

• blood group H alpha-2-fucosyltransferase
• guanosine diphosphofucose-galactoside 2-L-fucosyltransferase
• alpha-(1->2)-L-fucosyltransferase
• alpha-2-fucosyltransferase
• alpha-2-L-fucosyltransferase
• blood-group substance H-dependent fucosyltransferase
• guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase
• guanosine diphosphofucose-lactose fucosyltransferase
• GDP fucose-lactose fucosyltransferase
• guanosine diphospho-L-fucose-lactose fucosyltransferase
• guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase
  • alpha-L-fucosyltransferase, guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase
• H-gene-encoded beta-galactoside alpha1->2fucosyltransferase
• secretor-type beta-galactoside alpha1->2fucosyltransferase
• beta-galactoside alpha1->2fucosyltransferase
• GDP-L-fucose:lactose fucosyltransferase

References

• Basu S, Basu M, Chien JL . 1975 . Enzymatic synthesis of a blood group H-related glycosphingolipid by an alpha-fucosyltransferase from bovine spleen . J. Biol. Chem. . 250 . 2956 - 62 . 804484 . 8 . 10.1016/S0021-9258(19)41579-2 . free .
• Beyer TA, Hill RL . 1980 . Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland . J. Biol. Chem. . 255 . 5373 - 9 . 7372640 . 11 . 10.1016/S0021-9258(19)70796-0 . free .
• J. Evan Sadler . Beyer TA, Sadler JE, Hill RL . 1980 . Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland . J. Biol. Chem. . 255 . 5364 - 72 . 6246105 . 11 . 10.1016/S0021-9258(19)70795-9 . free .
• Book: Grollman AP . 1966 . GDP-L-fucose:lactose fucosyltransferase from mammary gland . GDP-l-fucose: Lactose fucosyltransferase from mammary gland . Methods Enzymol. . 8 . 351 - 353 . 10.1016/0076-6879(66)08065-0 . 978-0-12-181808-1 .