Gabexate Explained

Gabexate is a serine protease inhibitor which is used therapeutically (as gabexate mesilate) in the treatment of pancreatitis, disseminated intravascular coagulation,^[1] and as a regional anticoagulant for haemodialysis.^[2]

Notes and References

1. Yuksel M, Okajima K, Uchiba M, Okabe H . Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappaB and activator protein-1 in human monocytes . J. Pharmacol. Exp. Ther. . 305 . 1 . 298–305 . 2003 . 12649382 . 10.1124/jpet.102.041988 . 23518949 .
2. Cavallini G, Tittobello A, Frulloni L, Masci E, Mariana A, Di Francesco V . Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. Gabexate in digestive endoscopy--Italian Group . N. Engl. J. Med. . 335 . 13 . 919–23 . 1996 . 8786777 . 10.1056/NEJM199609263351302. free .