Furethidine Explained

Furethidine^{[1] [2] [3]} is a 4-phenylpiperidine derivative that is related to the clinically used opioid analgesic drug pethidine (meperidine),^[4] but with around 25x higher potency.^[5] According to another source, Furethidine is 500/30 = 16.7 x the potency of pethidine (table VII).^{[6] [7]}

Furethidine is not currently used in medicine and is a Class A/Schedule I drug which is controlled under UN drug conventions. It has similar effects to other opioid derivatives, such as analgesia, sedation, nausea and respiratory depression.^[8] In the United States it is a Schedule I Narcotic controlled substance with the ACSCN of 9626.^[9]

External links

• UNODC Bulletin on Narcotics 1961

Notes and References

1. GB . 797448 . Novel piperidine compounds and their production . Frearson PM, Stern ES . J F Macfarlan & Co Ltd . 2 July 1958 .
2. Frearson Peter Marshall; Stern Edward Severin, (1967 to Glaxo Lab Ltd).
3. ((Frearson, P. M.)), ((Hardy, D. G.)), ((Stern, E. S.)) . Journal of the Chemical Society (Resumed) . 426. Some new analogues of pethidine. Part IV. Substituents at the 1-position incorporating cyclic ether groups . 2103 . 1960 . 0368-1769 . 10.1039/jr9600002103.
4. Book: Maul C, Buschmann H, Sundermann B . Opioids: 3.3 Synthetic Opioids. . Analgesics . 2005 . 159–169 . Wiley-VCH . 978-3-527-30403-5 .
5. Casy AF, Parfitt RY. Opioid analgesics, chemistry and receptors. 1986, Plenum Press, New York. pp 234-235.
6. Blair, A. M. J. N.; Stephenson, R. P. (1960). "ANALGESIC ACTION OF ETHYL 4-PHENYLPIPERIDINE-4-CARBOXYLATES WITH OXYGENATED 1-SUBSTITUENTS". British Journal of Pharmacology and Chemotherapy. 15 (2): 247–253. doi:10.1111/j.1476-5381.1960.tb01239.x.
7. Lister, R. E. (1960). "PHARMACOLOGICAL ACTIONS OF TWO NEW PETHIDINE ANALOGUES". British Journal of Pharmacology and Chemotherapy. 15 (2): 254–259. doi:10.1111/j.1476-5381.1960.tb01240.x.
8. Cahal DA, Dare JG, Keith D . A sequential trial of analgesics in labour . The Journal of Obstetrics and Gynaecology of the British Commonwealth . 68 . 88–93 . February 1961 . 13689779 . 10.1111/j.1471-0528.1961.tb02689.x . 27397119 .
9. Web site: Controlled Substances - Alphabetical Order . 2020 . 9 . Diversion Control Division . Drug Enforcement Agency, U.S. Department of Justice .