Fructoselysine Explained

Fructoselysine is an Amadori adduct of glucose to lysine.[1]

It breaks down into furosine on acid-catalysed hydrolysis.[2] E. coli breaks it down using the enzymes fructoselysine-6-kinase and fructoselysine 6-phosphate deglycase into glucose 6-phosphate and lysine, a set of enzymes located on the frl (fructoselysine) operon.[3]

Notes and References

  1. Wiame. E. Delpierre. G. Collard. F. Van Schaftingen. E. Identification of a pathway for the utilization of the Amadori product fructoselysine in Escherichia coli.. The Journal of Biological Chemistry. 8 November 2002. 277. 45. 42523–9. 12147680. 10.1074/jbc.m200863200. free.
  2. Oimomi. M.. Hatanaka. H.. Ishikawa. K.. Kubota. S.. Yoshimura. Y.. Baba. S.. Increased fructose-lysine of nail protein in diabetic patients. Klinische Wochenschrift. May 1984. 62. 10. 477–478. 10.1007/BF01726910. 6431176. 36668875.
  3. Wiame. E. Van Schaftingen. E. Fructoselysine 3-epimerase, an enzyme involved in the metabolism of the unusual Amadori compound psicoselysine in Escherichia coli.. The Biochemical Journal. 15 March 2004. 378. Pt 3. 1047–52. 14641112. 10.1042/bj20031527. 1224009.

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