Fructose 5-dehydrogenase (NADP+) explained

fructose 5-dehydrogenase (NADP^+)
Ec Number:	1.1.1.124
Cas Number:	37250-53-6
Go Code:	0047903

In enzymology, a fructose 5-dehydrogenase (NADP⁺) is an enzyme that catalyzes the chemical reaction

D-fructose + NADP⁺

\rightleftharpoons 5-dehydro-D-fructose + NADPH + H⁺

Thus, the two substrates of this enzyme are D-fructose and NADP⁺, whereas its 3 products are 5-dehydro-D-fructose, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-fructose:NADP⁺ 5-oxidoreductase. Other names in common use include 5-ketofructose reductase (NADP⁺), 5-keto-D-fructose reductase (NADP⁺), fructose 5-(nicotinamide adenine dinucleotide phosphate), dehydrogenase, D-(-)fructose:(NADP⁺) 5-oxidoreductase, and fructose 5-dehydrogenase (NADP⁺).

References

• Ameyama M, Matsushita K, Shinagawa E, Adachi O . 1981 . 5-keto-D-Fructose reductase of Gluconobacter industrius Purification, crystallization and properties . Agric. Biol. Chem. . 45 . 863 - 869 . 10.1271/bbb1961.45.863 . 4 . free .
• Avigad G, Englard S, Pifko S . 1966 . 5-Keto-D-fructose. IV. A specific reduced nicotinamide adenine dinucleotide phosphate-linked reductase from Gluconobacter cerinus . J. Biol. Chem. . 241 . 373 - 8 . 4379259 . 2 .