Friedelin synthase explained

Friedelin synthase
Ec Number:	5.4.99.50

Friedelin synthase is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, friedelin-forming).^[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene

\rightleftharpoons friedelin

The enzyme from Kalanchoe daigremontiana also gives traces of other triterpenoids.

Notes and References

1. Wang Z, Yeats T, Han H, Jetter R . Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids . The Journal of Biological Chemistry . 285 . 39 . 29703–12 . September 2010 . 20610397 . 2943309 . 10.1074/jbc.m109.098871 . free .