Free fraction explained
The free fraction is a parameter in pharmacokinetics and receptor-ligand kinetics.One speaks of two different free fractions:
- Plasma free fraction, previously referred to as ƒ1,[1] is now referred to as ƒP according to consensus nomenclature.[2]
- Tissue free fraction (ƒND), previously referred to as ƒ2[1]
The plasma free fraction is the fraction of the ligand at equilibrium in blood plasma that is not bound to plasma proteins.
See also
References
Others
- Milak MS, Severance AJ, Ogden RT, Prabhakaran J, Kumar JS, Majo VJ, Mann JJ, Parsey RV . Modeling Considerations for 11C-CUMI-101, an Agonist Radiotracer for Imaging Serotonin 1A Receptor In Vivo with PET . . 49 . 4 . 587–596 . 2008 . 18344443 . 10.2967/jnumed.107.046540 . 3580231.
Notes and References
- Positron Emission Tomography Compartmental Models: A Basis Pursuit Strategy for Kinetic Modeling . . 22 . 4 . 1425–1439 . 2002 . 10.1097/00004647-200212000-00003 . 12468888 . Roger N. Gunn . Steve R. Gunn . Federico E. Turkheimer . Vincent J. Cunningham . Roger N. Gunn . Vincent J. Cunningham . Table
- Consensus nomenclature for in vivo imaging of reversibly binding radioligands . . 2007 . 27 . 9 . 1533–1539 . 10.1038/sj.jcbfm.9600493 . 17519979 . Cunningham . VJ . Delforge . J . Fujita . M . Gjedde . A . Gunn . RN . Holden . J . Houle . S . Huang . SC. Ichise . Masanori . Iida . Hidehiro . Ito . Hiroshi . Kimura . Yuichi . Koeppe . Robert A . Knudsen . Gitte M . Knuuti . Juhani . Lammertsma . Adriaan A . Laruelle . Marc . Logan . Jean . Maguire . Ralph Paul . Mintun . Mark A . Morris . Evan D . Parsey . Ramin . Price . Julie C . Slifstein . Mark . Sossi . Vesna . Suhara . Tetsuya . Votaw . John R . Wong . Dean F . Carson . Richard E . 8 . Innis. R.B.. free .
