Foslevodopa Explained

Foslevodopa is a drug which acts as a prodrug for levodopa, originally invented in the 1980s but not developed for medical use at that time.[1] It has more recently attracted renewed interest due to its improved pharmacokinetics compared to levodopa itself, and is now approved for use in a subcutaneous infusion as a fixed-dose combination with foscarbidopa for the treatment of Parkinson's disease, under the trade name Vyalev.[2] [3]

Notes and References

  1. Agin PP, Sayre RM, Pawelek JM . Phosphorylated mixed isomers of L-dopa increase melanin content in skins of Skh-2 pigmented hairless mice . Pigment Cell Research . 1987 . 1 . 3 . 137–142 . 3149738 . 10.1111/j.1600-0749.1987.tb00404.x .
  2. Poplawska-Domaszewicz K, Batzu L, Falup-Pecurariu C, Chaudhuri KR . Subcutaneous Levodopa: A New Engine for the Vintage Molecule . Neurology and Therapy . 13 . 4 . 1055–1068 . August 2024 . 38874708 . 10.1007/s40120-024-00635-4 . 11263521 .
  3. Fung VS, Aldred J, Arroyo MP, Bergquist F, Boon AJ, Bouchard M, Bray S, Dhanani S, Facheris MF, Fisseha N, Freire-Alvarez E, Hauser RA, Jeong A, Jia J, Kukreja P, Soileau MJ, Spiegel AM, Talapala S, Tarakad A, Urrea-Mendoza E, Zamudio J, Pahwa R . Continuous subcutaneous foslevodopa/foscarbidopa infusion for the treatment of motor fluctuations in Parkinson's disease: Considerations for initiation and maintenance . Clinical Parkinsonism & Related Disorders . 2024 . 10 . 100239 . 38419617 . 10.1016/j.prdoa.2024.100239 . 10900117 .

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