Formyl-CoA transferase explained

Formyl-CoA transferase
Ec Number:	2.8.3.16
Cas Number:	128826-27-7

In enzymology, a formyl-CoA transferase is an enzyme that catalyzes the chemical reaction

formyl-CoA + oxalate

\rightleftharpoons formate + oxalyl-CoA

Thus, the two substrates of this enzyme are formyl-CoA and oxalate, whereas its two products are formate and oxalyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is formyl-CoA:oxalate CoA-transferase. Other names in common use include formyl-coenzyme A transferase, and formyl-CoA oxalate CoA-transferase.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes,,, and .

References

• Baetz AL, Allison MJ . 1990 . Purification and characterization of formyl-coenzyme A transferase from Oxalobacter formigenes . J. Bacteriol. . 172 . 3537 - 40 . 2361939 . 7 . 213325 . 10.1128/jb.172.7.3537-3540.1990.
• Sidhu H, Ogden SD, Lung HY, Luttge BG, Baetz AL, Peck AB . 1997 . DNA sequencing and expression of the formyl coenzyme A transferase gene, frc, from Oxalobacter formigenes . J. Bacteriol. . 179 . 3378 - 81 . 9150242 . 10 . 10.1128/jb.179.10.3378-3381.1997 . 179125 .