Formononetin Explained

Formononetin is an O-methylated isoflavone.

Natural occurrences

Formononetin is found in a number of plants and herbs such as red clover.[1] Along with other phytoestrogens, it predominantly occurs in leguminous plants and Fabaceae, particularly in beans, such as green beans, lima beans, soy and many others, as the free aglycone or in form of its glucoside ononin.[2]

It can also be found in Maackia amurensis cell cultures.[3]

Pharmacodynamics

Formononetin promotes angiogenesis.[4] It is also involved in expressing the gene and proteins that are needed to make IgE.[5]

Derivatives

Ononin is the 7-O-β-D-glucopyranoside of formononetin.[6]

Notes and References

  1. Red Clover Isoflavones Biochanin A and Formononetin are Potent Ligands of the Human Aryl Hydrocarbon Receptor . Medjakovic, S. . Jungbauer, A. . 2008 . The Journal of Steroid Biochemistry and Molecular Biology . 108 . 1–2 . 171–177 . 18060767 . 10.1016/j.jsbmb.2007.10.001 . 206495959 .
  2. Web site: Iowa State University Database on the Isoflavone Content of Foods, Release 1.3 . 2002 . USDA . 2011-02-13 . https://web.archive.org/web/20121102050440/http://www.nal.usda.gov/fnic/foodcomp/Data/isoflav/isoflav.html . 2012-11-02 . dead .
  3. 10.1016/S0367-326X(00)00129-5. 10925005. Isoflavonoid production by callus cultures of Maackia amurensis. Fitoterapia. 71. 4. 365–72. 2000. Fedoreyev. S.A. Pokushalova. T.V. Veselova. M.V. Glebko. L.I. Kulesh. N.I. Muzarok. T.I. Seletskaya. L.D. Bulgakov. V.P. Zhuravlev. Yu.N.
  4. 10.1038/srep16815. 26568398. 4645220. Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway. Scientific Reports. 5. 16815. 2015. Li. Shang. Dang. Yuanye. Zhou. Xuelin. Huang. Bin. Huang. Xiaohui. Zhang. Zherui. Kwan. Yiu Wa. Chan. Shun Wan. Leung. George Pak Heng. Lee. Simon Ming Yuen. Hoi. Maggie Pui Man. 2015NatSR...516815L.
  5. Web site: 2022-04-01 . This plant-based compound could finally cure food allergies . 2022-04-04 . ZME Science . en-US.
  6. Book: Chinese Materia Medica: Chemistry, Pharmacology and Applications . registration . You-Ping Zhu . 622 . 9057022850. 1998-05-28 . CRC Press .

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