Fluroxene Explained

Fluroxene (INN, USAN; brand name Fluoromar), or 2,2,2-trifluoroethyl vinyl ether, is a volatile, inhalational anesthetic.^{[1] [2]} It was synthesized in 1951, and was introduced for clinical use in 1954, but was voluntarily withdrawn from the market in 1974 due to its potential flammability and accumulating evidence that it could cause organ toxicity.^[3] In any case, prior to being discontinued, it had largely been superseded by halothane.^[4] Fluroxene is metabolized to 2,2,2-trifluoroethanol, a compound responsible for some of the toxicity seen with fluroxene use.^{[5] [6]}

See also

• Divinyl ether

Notes and References

1. Book: Stoelting RK, Hillier SC . Inhaled Anesthetics . Pharmacology and Physiology in Anesthetic Practice. https://books.google.com/books?id=lHhGtkvOoM0C&pg=PT142. 11 January 2012. Lippincott Williams & Wilkins. 978-1-4511-6583-8. 142–.
2. Book: Jakob AK, Kopp SL, Bacon DR, Smith HM . Chapter 1: the History of Anesthesia . Barash PG, Cullen BF, Stoelting RK, Cahalan M, Stock MC . Clinical Anesthesia. https://books.google.com/books?id=vGtSChnRRJ8C&pg=PT113. 1 January 2011. Lippincott Williams & Wilkins. 978-1-4511-2297-8. 113–.
3. Book: Lichtiger M, Moya F . Introduction to the practice of anesthesia. 1 January 1978. Medical Dept., Harper & Row. 978-0-06-141534-0.
4. Book: Acta anaesthesiologica Belgica. 1974. Acta Medica Belgica .
5. Fiserova-Bergerova V . Metabolism and toxicity of 2,2,2-trifluoroethyl vinyl ether . Environmental Health Perspectives . 21 . 225–230 . December 1977 . 25763 . 1475355 . 10.1289/ehp.7721225 .
6. Kaminsky LS, Fraser JM . Multiple aspects of the toxicity of fluroxene and its metabolite 2,2,2-trifluoroethanol . Critical Reviews in Toxicology . 19 . 2 . 87–112 . 1988 . 2906849 . 10.3109/10408448809014901.