Fluorothreonine transaldolase explained
Fluorothreonine transaldolase |
Ec Number: | 2.2.1.8 |
In enzymology, a fluorothreonine transaldolase is an enzyme that catalyzes the chemical reaction
L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-
L-threonine
Thus, the two substrates of this enzyme are L-threonine and fluoroacetaldehyde, whereas its two products are acetaldehyde and 4-fluoro-L-threonine.
This enzyme belongs to the family of transferases, specifically those transferring aldehyde or ketonic groups (transaldolases and transketolases, respectively). The systematic name of this enzyme class is fluoroacetaldehyde:L-threonine aldehydetransferase.
References
- Murphy CD, O'Hagan D, Schaffrath C . 2001 . Identification of a PLP-Dependent Threonine Transaldolase: A Novel Enzyme Involved in 4-Fluorothreonine Biosynthesis in Streptomyces cattleya This work was supported by the Biotechnological and Biological Sciences Research Council and the University of St Andrews . Angew. Chem. Int. Ed. Engl. . 40 . 4479 - 4481 . 12404452 . 10.1002/1521-3773(20011203)40:23<4479::AID-ANIE4479>3.0.CO;2-1 . 23 .
- Murphy CD, Schaffrath C, O'Hagan D . 2003 . Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya . Chemosphere . 52 . 455 - 61 . 12738270 . 10.1016/S0045-6535(03)00191-7 . 2 .