Fluoroacetaldehyde dehydrogenase explained

Fluoroacetaldehyde dehydrogenase
Ec Number:	1.2.1.69

In enzymology, a fluoroacetaldehyde dehydrogenase is an enzyme that catalyzes the chemical reaction

fluoroacetaldehyde + NAD⁺ + H₂O

\rightleftharpoons fluoroacetate + NADH + 2 H⁺

The 3 substrates of this enzyme are fluoroacetaldehyde, NAD⁺, and H₂O, whereas its 3 products are fluoroacetate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is fluoroacetaldehyde:NAD+ oxidoreductase.

References

• Murphy CD, Moss SJ, O'Hagan D . 2001 . Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya . Appl. Environ. Microbiol. . 67 . 4919 - 21 . 11571203 . 10.1128/AEM.67.10.4919-4921 . 10 . 93250 .
• Murphy CD, Schaffrath C, O'Hagan D . 2003 . Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya . Chemosphere . 52 . 455 - 61 . 12738270 . 10.1016/S0045-6535(03)00191-7 . 2 .