FLOT1 explained

Flotillin-1 is a protein that in humans is encoded by the FLOT1 gene.^[1]

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein.^[2] The function of flotillin 1 has not been determined.^[1]

Interactions

FLOT1 has been shown to interact with SORBS1.^{[3] [4] [5]}

References

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Volonte D, Galbiati F, Li S . Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe. . J. Biol. Chem. . 274 . 18 . 12702–9 . 1999 . 10212252 . 10.1074/jbc.274.18.12702 . etal. free .
• Hazarika P, Dham N, Patel P . Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation. . J. Cell. Biochem. . 75 . 1 . 147–59 . 1999 . 10462713 . 10.1002/(SICI)1097-4644(19991001)75:1<147::AID-JCB15>3.0.CO;2-D . 12223151 . etal.
• Hu RM, Han ZG, Song HD . Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 17 . 9543–8 . 2000 . 10931946 . 10.1073/pnas.160270997 . 16901 . etal. 2000PNAS...97.9543H . free .
• Baumann CA, Ribon V, Kanzaki M . CAP defines a second signalling pathway required for insulin-stimulated glucose transport. . Nature . 407 . 6801 . 202–7 . 2000 . 11001060 . 10.1038/35025089 . etal. 2000Natur.407..202B . 2027.42/62940 . 4334519 . free .
• Zhang QH, Ye M, Wu XY . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 . etal.
• Salzer U, Prohaska R . Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts. . Blood . 97 . 4 . 1141–3 . 2001 . 11159550 . 10.1182/blood.V97.4.1141 .
• Edgar AJ, Polak JM . Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals. . Int. J. Biochem. Cell Biol. . 33 . 1 . 53–64 . 2001 . 11167132 . 10.1016/S1357-2725(00)00069-8 .
• Kimura A, Baumann CA, Chiang SH, Saltiel AR . The sorbin homology domain: a motif for the targeting of proteins to lipid rafts. . Proc. Natl. Acad. Sci. U.S.A. . 98 . 16 . 9098–103 . 2001 . 11481476 . 10.1073/pnas.151252898 . 55379 . 2001PNAS...98.9098K . free .
• Stuermer CA, Lang DM, Kirsch F . Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2. . Mol. Biol. Cell . 12 . 10 . 3031–45 . 2002 . 11598189 . 10.1091/mbc.12.10.3031. 60153 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal . 2002PNAS...9916899M. free .
• Girardot N, Allinquant B, Duyckaerts C . [Lipid rafts, flotillin-1 and Alzheimer disease] . J. Soc. Biol. . 197 . 3 . 223–9 . 2004 . 14708344 . 10.1051/jbio/2003197030223. 86221484 .
• Wakasugi K, Nakano T, Kitatsuji C, Morishima I . Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein. . Biochem. Biophys. Res. Commun. . 318 . 2 . 453–60 . 2004 . 15120622 . 10.1016/j.bbrc.2004.04.045 .
• Haglund K, Ivankovic-Dikic I, Shimokawa N . Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. . J. Cell Sci. . 117 . Pt 12 . 2557–68 . 2004 . 15128873 . 10.1242/jcs.01148 . 14083271 . etal.
• Bared SM, Buechler C, Boettcher A . Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells. . Mol. Biol. Cell . 15 . 12 . 5399–407 . 2005 . 15469992 . 10.1091/mbc.E04-03-0182 . 532019 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Jacobowitz DM, Kallarakal AT . Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain. . Neurotoxicity Research . 6 . 4 . 245–57 . 2005 . 15545008 . 10.1007/BF03033435 . 22168131 .
• Pope SN, Lee IR . Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. . J. Steroid Biochem. Mol. Biol. . 94 . 1–3 . 203–8 . 2005 . 15862967 . 10.1016/j.jsbmb.2005.01.007 . 9746088 .
• Glebov OO, Bright NA, Nichols BJ . Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells. . Nat. Cell Biol.. 8 . 1 . 46–54 . 2006 . 16341206 . 10.1038/ncb1342 . 36695735 .

Notes and References

1. Web site: Entrez Gene: FLOT1 flotillin 1.
2. Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF . Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins . J. Biol. Chem. . 272 . 21 . 13793–802 . May 1997 . 9153235 . 10.1074/jbc.272.21.13793 . free .
3. Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I . Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites . J. Cell Sci. . 117 . Pt 12 . 2557–68 . May 2004 . 15128873 . 10.1242/jcs.01148 . 14083271 .
4. Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR . CAP defines a second signalling pathway required for insulin-stimulated glucose transport . Nature . 407 . 6801 . 202–7 . September 2000 . 11001060 . 10.1038/35025089 . 2000Natur.407..202B . 2027.42/62940 . 4334519 . free .
5. Kimura A, Baumann CA, Chiang SH, Saltiel AR . The sorbin homology domain: a motif for the targeting of proteins to lipid rafts . Proc. Natl. Acad. Sci. U.S.A. . 98 . 16 . 9098–103 . July 2001 . 11481476 . 55379 . 10.1073/pnas.151252898 . 2001PNAS...98.9098K . free .