Flavonol synthase explained

flavonol synthase
Ec Number:	1.14.11.23
Cas Number:	146359-76-4
Go Code:	0045431

In enzymology, a flavonol synthase is an enzyme that catalyzes the following chemical reaction :

dihydroflavonol + 2-oxoglutarate +

\rightleftharpoons a flavonol + succinate + C + H₂O

The 3 substrates of this enzyme are dihydroflavonol, 2-oxoglutarate, and O₂, whereas its 4 products are flavonol, succinate, CO₂, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from with 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor. The systematic name of this enzyme class is dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase. This enzyme participates in flavonoid biosynthesis.

References

• Wellmann F, Lukacin R, Moriguchi T, Britsch L, Schiltz E, Matern U . 2002 . Functional expression and mutational analysis of flavonol synthase from Citrus unshiu . Eur. J. Biochem. . 269 . 4134 - 42 . 12180990 . 10.1046/j.1432-1033.2002.03108.x . 16 . free .
• Lukacin R, Wellmann F, Britsch L, Martens S, Matern U . 2003 . Flavonol synthase from Citrus unshiu is a bifunctional dioxygenase . . 62 . 287 - 92 . 12620339 . 10.1016/S0031-9422(02)00567-8 . 3 .
• Martens S, Forkmann G, Britsch L, Wellmann F, Matern U, Lukacin R . 2003 . Divergent evolution of flavonoid 2-oxoglutarate-dependent dioxygenases in parsley . FEBS Lett. . 544 . 93 - 8 . 12782296 . 10.1016/S0014-5793(03)00479-4 . 1-3 . free .
• CJ . 2004 . Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis: anthocyanidin synthase, flavonol synthase, and flavanone 3beta-hydroxylase . J. Biol. Chem. . 279 . 1206 - 16 . 14570878 . 10.1074/jbc.M309228200 . Nakajima . J . Welford . RW . Yamazaki . M . Saito . K . Schofield . CJ . 2 . free .