Flavokavain B Explained

Flavokavain B is a flavokavain found in the kava plant.^[1] In 2010 a paper was published identifying it as a glutathione-depleting hepatotoxin.^[2]

FKB is said by enthusiasts to occur at higher concentrations in "tudei" kava strains, which are generally considered less desirable.

See also

• Kavalactone

External links

• Flavokawain B at the United States National Library of Medicine

Notes and References

1. Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses. Phytochemistry. February 2002. H. Ranjith W.. Dharmaratne. N. P. Dhammika Nanayakkara . Ikhlas A. Khan . 11830162. 59. 4. 429–33. 10.1016/S0031-9422(01)00443-5.
2. Zhou P., Gross S., Liu J.-H., Yu B.-Y., Feng L.-L., Nolta J., Sharma V., Piwnica-Worms D., Qiu S.X 'Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways . FASEB Journal 2010 24:12 (4722-4732)