Flavokavain A Explained

Flavokavain A is a flavokavain found in the kava plant.^[1] It induces apoptosis in bladder cancer cells via a Bax protein-dependent and mitochondria-dependent apoptotic pathway.^[2]

Flavokavains A and B enhance hepatotoxicity of paracetamol, underscoring a potentially serious interaction between paracetamol and kava.

See also

• Kavalactone

External links

• Flavokawain A at the United States National Library of Medicine

Notes and References

1. Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses. Phytochemistry. February 2002. H. Ranjith W.. Dharmaratne. N. P. Dhammika Nanayakkara . Ikhlas A. Khan . 59. 4. 429–33. 11830162 . 10.1016/S0031-9422(01)00443-5 .
2. Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice.. Zi X, Simoneau AR . Cancer Research. 15833884. 10.1158/0008-5472.CAN-04-3803. 65. 8. April 2005. 3479–86. free.