Flavastacin Explained

Flavastacin
Ec Number:3.4.24.76
Cas Number:167973-66-2

Flavastacin is an enzyme.[1] This enzyme catalyses the following chemical reaction

Hydrolyses polypeptides on the amino-side of Asp in -Xaa-Asp-. Acts very slowly on -Xaa-Glu

This zinc metalloendopeptidase belong to the peptidase family M12. It has recently been described as cleaving specifically after N-glycosylated asparagine, making it a potentially useful as a tool to analytically characterize glycoproteins.[2]

Notes and References

  1. Molecular cloning and sequence analysis of flavastacin: an O-glycosylated prokaryotic zinc metalloendopeptidase . Tarentino, A.L. . Quinones, G. . Grimwood, B.G. . Hauer, C.R. . Plummer, T.H. Jr. . Arch. Biochem. Biophys. . 1995 . 319 . 281–285 . 7771796 . 10.1006/abbi.1995.1293.
  2. Pralow A, Hoffmann M, Nguyen-Khuong T, Rapp E, Reichl U . Improvement of the glycoproteomic toolbox with the discovery of a unique C-terminal cleavage specificity of flavastacin for N-glycosylated asparagine . Sci Rep . 7 . 1 . 11419 . 2017 . 28900186 . 5595805 . 10.1038/s41598-017-11668-1 .

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