Firocoxib Explained

Verifiedfields:changed
Verifiedrevid:443742691
Alt2:Firocoxib molecule
Tradename:Equioxx, Previcox
Dailymedid:Firocoxib
Routes Of Administration:By mouth
Atcvet:yes
Atc Prefix:M01
Atc Suffix:AH90
Legal Au:S4
Legal Ca:Rx-only
Legal Ca Comment:[1]
Legal Uk:POM
Legal Us:Rx-only
Legal Us Comment:[2] [3] [4]
Legal Eu:Rx-only
Legal Eu Comment:[5] [6] [7]
Cas Number:189954-96-9
Pubchem:208910
Drugbank:DB09217
Chemspiderid:181008
Unii:Y6V2W4S4WT
Kegg:D03712
Chebi:76136
Chembl:69998
Iupac Name:3-(Cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one
C:17
H:20
O:5
S:1
Smiles:O=C2OC(C(=C2\OCC1CC1)\c3ccc(cc3)S(=O)(=O)C)(C)C
Stdinchi:1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3
Stdinchikey:FULAPETWGIGNMT-UHFFFAOYSA-N

Firocoxib, sold under the brand names Equioxx and Previcox among others, is a nonsteroidal anti-inflammatory drug of the COX-2 inhibitor (coxib) class, approved for use in horses (Equioxx) and for use in dogs (Previcox).[8] Firocoxib was the first COX-2 inhibitor approved by the U.S. Food and Drug Administration for horses.[9] Firocoxib is not intended or approved for use in human medicine.[10]

Firocoxib, manufactured by Merial, was approved for veterinary use in the United States for dogs in July 2004, and for horses in July 2007, as an oral paste (Equioxx) and July 2016, as tablets.[11]

Firocoxib is also available as a generic medication for horses[12] and for dogs.[13]

Notes and References

  1. Web site: Product information . . 22 October 2009 . 9 February 2024.
  2. Web site: Equioxx- firocoxib tablet, chewable . DailyMed . 14 July 2020 . 2 August 2022 . 3 August 2022 . https://web.archive.org/web/20220803063530/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3f891a61-ce58-4cc1-97e2-a161907ea8eb . live .
  3. Web site: Equioxx- firocoxib paste . DailyMed . 24 February 2022 . 2 August 2022 . 3 August 2022 . https://web.archive.org/web/20220803063531/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=17db1d7d-3683-4030-9039-296a882cc072 . live .
  4. Web site: Previcox- firocoxib tablet, chewable . DailyMed . 23 July 2020 . 2 August 2022 . 3 August 2022 . https://web.archive.org/web/20220803063530/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e6d96ec6-04a4-4986-ac9d-82aa79b28bd4 . live .
  5. Web site: Equioxx EPAR . European Medicines Agency (EMA) . 2 August 2022 . 25 April 2022 . https://web.archive.org/web/20220425005842/https://www.ema.europa.eu/en/medicines/veterinary/EPAR/equioxx . live .
  6. Web site: Previcox EPAR . European Medicines Agency (EMA) . 2 August 2022 . 31 July 2021 . https://web.archive.org/web/20210731052019/https://www.ema.europa.eu/en/medicines/veterinary/EPAR/previcox . live .
  7. Web site: Coxatab EPAR . European Medicines Agency (EMA) . 17 June 2022 . 9 February 2024.
  8. Rangel-Nava A, Ramírez-Uribe JM, Recillas-Morales S, Ibancovichi-Camarillo JA, Venebra-Muñoz A, Sánchez-Aparicio P . Pharmacological Regulation in the USA and Pharmacokinetics Parameters of Firocoxib, a Highly Selective Cox-2, by Pain Management in Horses . Journal of Equine Veterinary Science . 77 . 36–42 . June 2019 . 31133314 . 10.1016/j.jevs.2019.02.007 . 86530623 .
  9. Web site: New NSAID Equioxx (firocoxib) Approved by USEF . 2 July 2007 . 18 April 2008 . The Horse . 18 May 2011 . https://web.archive.org/web/20110518185548/http://www.thehorse.com/ViewArticle.aspx?ID=9896 . live .
  10. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/veterinary/000142/WC500065936.pdf Equioxx
  11. Web site: 1 July 2007 . Merial launches first firocoxib for horses . 3 October 2023 . DVM 360 .
  12. Web site: FDA Approves the First Generic Firocoxib Tablets for Horses . U.S. Food and Drug Administration (FDA) . 1 August 2022 . 2 August 2022 . 3 August 2022 . https://web.archive.org/web/20220803051550/https://www.fda.gov/animal-veterinary/cvm-updates/fda-approves-first-generic-firocoxib-tablets-horses . live .
  13. Web site: FDA Approves the First Generic Firocoxib Tablets for Dogs . U.S. Food and Drug Administration . 7 June 2022 . 2 August 2022 . 3 August 2022 . https://web.archive.org/web/20220803052501/https://www.fda.gov/animal-veterinary/cvm-updates/fda-approves-first-generic-firocoxib-chewable-tablets-dogs . live .

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