Fetuin-B Explained

Fetuin-B is a protein that in humans is encoded by the FETUB gene.^[1]

The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells.^[2]

See also

• Fetuin-A (alpha-2-HS-glycoprotein)

Further reading

• Haidar M, Seddiki N, Gluckman JC, Gattegno L . Carbohydrate binding properties of the envelope glycoproteins of human immunodeficiency virus type 1. . Glycoconj. J. . 9 . 6 . 315–23 . 1993 . 1284814 . 10.1007/BF00731092 . 7976435 .
• Hillier LD, Lennon G, Becker M . Generation and analysis of 280,000 human expressed sequence tags. . Genome Res. . 6 . 9 . 807–28 . 1997 . 8889549 . 10.1101/gr.6.9.807 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Denecke B, Gräber S, Schäfer C . Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A. . Biochem. J. . 376 . Pt 1 . 135–45 . 2003 . 12943536 . 10.1042/BJ20030676 . 1223762 . etal.
• Wajih N, Borras T, Xue W . Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells: evidence for an uptake mechanism for serum fetuin. . J. Biol. Chem. . 279 . 41 . 43052–60 . 2004 . 15280384 . 10.1074/jbc.M407180200 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Hsu SJ, Nagase H, Balmain A . Allan Balmain . Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity. . Genome . 47 . 5 . 931–46 . 2005 . 15499407 . 10.1139/g04-043 .
• Liu T, Qian WJ, Gritsenko MA . Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. . J. Proteome Res. . 4 . 6 . 2070–80 . 2006 . 16335952 . 10.1021/pr0502065 . 1850943 . etal.
• Coen G, Ballanti P, Balducci A . Renal osteodystrophy: alpha-Heremans Schmid glycoprotein/fetuin-A, matrix GLA protein serum levels, and bone histomorphometry. . Am. J. Kidney Dis. . 48 . 1 . 106–13 . 2006 . 16797392 . 10.1053/j.ajkd.2006.03.083 . etal. free .

Notes and References

1. Olivier E, Soury E, Ruminy P, Husson A, Parmentier F, Daveau M, Salier JP . Fetuin-B, a second member of the fetuin family in mammals . Biochem J . 350 Pt 2 . 2. 589–97 . Jan 2001 . 10947975 . 1221288 . 10.1042/0264-6021:3500589.
2. Web site: Entrez Gene: FETUB fetuin B.