Festuclavine dehydrogenase explained

Festuclavine dehydrogenase
Ec Number:	1.5.1.44

Festuclavine dehydrogenase (FgaFS, festuclavine synthase) is an enzyme with systematic name festuclavine:NAD⁺ oxidoreductase.^[1] This enzyme catalyses the following chemical reaction

festuclavine + NAD⁺

\rightleftharpoons 6,8-dimethyl-6,7-didehydroergoline + NADH + H⁺

The enzyme takes part in the biosynthesis of fumigaclavine C.

Notes and References

1. Wallwey C, Matuschek M, Xie XL, Li SM . Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3 . Organic & Biomolecular Chemistry . 8 . 15 . 3500–8 . August 2010 . 20526482 . 10.1039/c003823g .