Ferric-chelate reductase (NADPH) explained

Ferric-chelate reductase (NADPH)
Ec Number:	1.16.1.9
Cas Number:	120720-17-4

Ferric-chelate reductase (NADPH) (ferric chelate reductase, iron chelate reductase, NADPH:Fe³⁺-EDTA reductase, NADPH-dependent ferric reductase, yqjH (gene)) is an enzyme with systematic name Fe(II):NADP⁺ oxidoreductase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

2 Fe(II) + 2 apo-siderophore + NADP⁺ + H⁺

\rightleftharpoons 2 Fe(III)-siderophore + NADPH

Ferric-chelate reductase contains FAD.

See also

• Ferric-chelate reductase

Notes and References

1. Bamford VA, Armour M, Mitchell SA, Cartron M, Andrews SC, Watson KA . Preliminary X-ray diffraction analysis of YqjH from Escherichia coli: a putative cytoplasmic ferri-siderophore reductase . Acta Crystallographica Section F . 64 . Pt 9 . 792–6 . September 2008 . 18765906 . 2531270 . 10.1107/S174430910802352X .
2. Wang S, Wu Y, Outten FW . Fur and the novel regulator YqjI control transcription of the ferric reductase gene yqjH in Escherichia coli . Journal of Bacteriology . 193 . 2 . 563–74 . January 2011 . 21097627 . 3019823 . 10.1128/JB.01062-10 .
3. Miethke M, Hou J, Marahiel MA . The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli . Biochemistry . 50 . 50 . 10951–64 . December 2011 . 22098718 . 10.1021/bi201517h .