Fenpiverinium Explained

Fenpiverinium is an anticholinergic and antispasmodic compound;^[1] it is marketed as a combination drug with pitofenone hydrochloride and either nimesulide or metamizole in Eastern Europe and India to treat smooth muscle spasms and pain.^[2]

The combination with metamizole was removed from the market in Lithuania for safety reasons in 2000^[3] and a boxed warning against use by children and adolescents was added in Serbia in 2005.^[4] In 2016 India banned marketing of the combination with nimesulide along with 344 other combination drugs;^{[5] [6]} the order was overturned in December and appealed by the Government in January 2017.^[7]

Notes and References

1. Proposed INNs List 26. WHO Chronicle. 1971. 25. 9. . Recommended INNs List 12. WHO Chronicle. 1973. 26. 10.
2. Book: Vardanyan R . Piperidine-Based Drug Discovery. 2017. Elsevier. 9780128134283. en.
3. Book: Consolidated List of Products - Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or Not Approved by Governments, Twelfth Issue. 2005. WHO. 305. https://web.archive.org/web/20141108234228/http://apps.who.int/medicinedocs/en/m/abstract/Js16780e/. dead. November 8, 2014.
4. Book: Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments, Fourteenth Issue. 2009. WHO. 35.
5. News: Health ministry bans 344 fixed dose combination drugs. The Times of India. March 14, 2016.
6. Web site: Gazette of India D. L.-33004/99. PART II—Section 3—Sub-section (ii). Government of India. March 10, 2016. 2017-06-22. 2018-08-26. https://web.archive.org/web/20180826214315/http://cdsco.nic.in/writereaddata/SO%20705(E)%20TO%201048(E)%20DATED%2010-03-2016.pdf. dead.
7. News: Govt moves SC to enforce ban on 344 Fixed Dose Combination drugs. The Times of India. January 31, 2017.