Phenindione Explained

Phenindione is an anticoagulant which functions as a Vitamin K antagonist.

Phenindione was introduced in the early 1950s. It acts similar to warfarin, but it has been associated with hypersensitivity reactions, so it is rarely used and warfarin is preferred.[1] [2]

Notes and References

  1. Naisbitt DJ, Farrell J, Chamberlain PJ, Hopkins JE, Berry NG, Pirmohamed M, Park BK . Characterization of the T-cell response in a patient with phenindione hypersensitivity . The Journal of Pharmacology and Experimental Therapeutics . 313 . 3 . 1058–65 . June 2005 . 15743920 . 10.1124/jpet.105.083758 . 17052792 .
  2. Book: Sweetman SC . 2009 . Martindale: The Complete Drug Reference . 36th . Pharmaceutical Press. London . "Phenindione", p. 1369.

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