Far upstream element-binding protein 1 explained

Far upstream element-binding protein 1 is a protein that in humans is encoded by the FUBP1 gene.^{[1] [2]}

This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase.

Interactions

Far upstream element-binding protein 1 has been shown to interact with MAPK14^[3] and SMN1.^[4]

Clinical Significance

FUBP1 gene deletion forms part of the 1p/19q codeletion mutation seen in oligodendroglioma, a form of primary brain tumour.^[5] CIC gene is also lost in the 1p/19q codeletion mutation.

Further reading

• Williams BY, Hamilton SL, Sarkar HK . The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain . FEBS Lett. . 470 . 2 . 207–10 . 2000 . 10734235 . 10.1016/S0014-5793(00)01320-X . 28330997 .
• Liu J, He L, Collins I . The FBP interacting repressor targets TFIIH to inhibit activated transcription . Mol. Cell . 5 . 2 . 331–41 . 2000 . 10882074 . 10.1016/S1097-2765(00)80428-1 . etal. free .
• Markovtsov V, Nikolic JM, Goldman JA . Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein . Mol. Cell. Biol. . 20 . 20 . 7463–79 . 2000 . 11003644 . 10.1128/MCB.20.20.7463-7479.2000 . 86300 . etal.
• He L, Weber A, Levens D . Nuclear targeting determinants of the far upstream element binding protein, a c-myc transcription factor . Nucleic Acids Res. . 28 . 22 . 4558–65 . 2000 . 11071946 . 10.1093/nar/28.22.4558 . 113884 .
• Vindigni A, Ochem A, Triolo G, Falaschi A . Identification of human DNA helicase V with the far upstream element-binding protein . Nucleic Acids Res. . 29 . 5 . 1061–7 . 2001 . 11222755 . 10.1093/nar/29.5.1061 . 29729 .
• Liu J, Akoulitchev S, Weber A . Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum . Cell . 104 . 3 . 353–63 . 2001 . 11239393 . 10.1016/S0092-8674(01)00223-9 . etal. free .
• Braddock DT, Louis JM, Baber JL . Structure and dynamics of KH domains from FBP bound to single-stranded DNA . Nature . 415 . 6875 . 1051–6 . 2002 . 11875576 . 10.1038/4151051a . 2002Natur.415.1051B . 4401103 . etal.
• Rappsilber J, Ryder U, Lamond AI, Mann M . Large-scale proteomic analysis of the human spliceosome . Genome Res. . 12 . 8 . 1231–45 . 2002 . 12176931 . 10.1101/gr.473902 . 186633 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Kim MJ, Park BJ, Kang YS . Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation . Nat. Genet. . 34 . 3 . 330–6 . 2003 . 12819782 . 10.1038/ng1182 . 41006480 . etal.
• Brandenberger R, Wei H, Zhang S . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 . etal.
• Beausoleil SA, Jedrychowski M, Schwartz D . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . etal. 2004PNAS..10112130B . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Kouzine F, Liu J, Sanford S . The dynamic response of upstream DNA to transcription-generated torsional stress . Nat. Struct. Mol. Biol. . 11 . 11 . 1092–100 . 2004 . 15502847 . 10.1038/nsmb848 . 28956216 . etal.
• Rush J, Moritz A, Lee KA . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 . etal.
• Stelzl U, Worm U, Lalowski M . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . etal. free . 11858/00-001M-0000-0010-8592-0 . free .
• Fautsch MP, Vrabel AM, Johnson DH . The identification of myocilin-associated proteins in the human trabecular meshwork . Exp. Eye Res. . 82 . 6 . 1046–52 . 2006 . 16289162 . 10.1016/j.exer.2005.09.016 .
• Liu J, Kouzine F, Nie Z . The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression . EMBO J. . 25 . 10 . 2119–30 . 2006 . 16628215 . 10.1038/sj.emboj.7601101 . 1462968 . etal.
• Ko HS, Kim SW, Sriram SR . Identification of far upstream element-binding protein-1 as an authentic Parkin substrate . J. Biol. Chem. . 281 . 24 . 16193–6 . 2006 . 16672220 . 10.1074/jbc.C600041200 . etal. free .

Notes and References

1. Duncan R, Bazar L, Michelotti G, Tomonaga T, Krutzsch H, Avigan M, Levens D . A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif . Genes Dev . 8 . 4 . 465–80 . April 1994 . 8125259 . 10.1101/gad.8.4.465 . free .
2. Web site: Entrez Gene: FUBP1 far upstream element (FUSE) binding protein 1.
3. Kim . Min Jung . Park Bum-Joon . Kang Young-Sun . Kim Hyoung June . Park Jae-Hyun . Kang Jung Woo . Lee Sang Won . Han Jung Min . Lee Han-Woong . Kim Sunghoon . July 2003 . Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation . Nat. Genet. . 34 . 3 . 330–6 . United States. 1061-4036. 12819782 . 10.1038/ng1182 . 41006480 .
4. Williams . B Y . Hamilton S L . Sarkar H K . March 2000 . The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain . FEBS Lett. . 470 . 2 . 207–10 . NETHERLANDS. 0014-5793. 10734235 . 10.1016/S0014-5793(00)01320-X . 28330997 .
5. Weller . Michael . Nature Reviews. Clinical Oncology . 10.1038/s41571-020-00447-z . 8 December 2020. 18 . 170–186 . EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood. 3 . 33293629 . 7904519 .