Falcarindiol Explained

Falcarindiol is a polyyne found in carrot roots which has antifungal activity.[1] [2] Falcarindiol is the main compound responsible for bitterness in carrots.[3] Falcarindiol and other falcarindiol-type polyacetylenes are also found in many other plants of the family Apiaceae, including some commonly used seasonings such as dill and parsley.[4]

A variety of bioactivities have been reported for falcaridiol and the falcarindiol-type polyacetylenes,[5] [6] [7] and because of potential health-promoting metabolic effects these compounds are studied as potential nutraceuticals.[8] Falcarindiol is the most-active among several polyynes found in Devil's club (Oplopanax horridus) that inhibit cell proliferation.[9]

See also

Notes and References

  1. Garrod . B. . Cis-heptadeca-1,9-diene-4,6-diyne-3,8-diol, an antifungal polyacetylene from carrot root tissue . Physiological Plant Pathology . 1978 . 13 . 2 . 241–246 . 10.1016/0048-4059(78)90039-5 .
  2. Kemp, M. S. . Falcarindiol: An antifungal polyacetylene from Aegopodium podagraria . Phytochemistry . 1978 . 17 . 5 . 1002 . 10.1016/S0031-9422(00)88669-0 . 1978PChem..17.1002K .
  3. 12797757 . Czepa . A. . Hofmann . T. . Structural and sensory characterization of compounds contributing to the bitter off-taste of carrots (Daucus carota L.) and carrot puree . Journal of Agricultural and Food Chemistry . 2003 . 51 . 13 . 3865–3873 . 10.1021/jf034085+ .
  4. Christensen, L. P. . Brandt, K. . Bioactive polyacetylenes in food plants of the Apiaceae family: Occurrence, bioactivity and analysis . Journal of Pharmaceutical and Biomedical Analysis . 2006 . 41 . 3 . 683–693 . 10.1016/j.jpba.2006.01.057 . 16520011 .
  5. Jin, H. R. . Zhao, J. . Zhang, Z. . Liao, Y. . Wang, C. Z. . Huang, W. H. . Li, S. P. . He, T. C. . Yuan, C. S. . Du, W. . The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress . Cell Death and Disease . 2012 . 3 . 8 . e376 . 10.1038/cddis.2012.122 . 22914324 . 3434669 .
  6. Wyrembek, P. . Negri, R. . Kaczor, P. . Czyżewska, M. . Appendino, G. . Mozrzymas, J. W. . Falcarindiol allosterically modulates GABAergic currents in cultured rat hippocampal neurons . Journal of Natural Products . 2012 . 75 . 4 . 610–616 . 10.1021/np2008522 . 22432736 .
  7. 10.3389/fphar.2017.00596. free. The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability. 2017. Wang. Limei. Palme. Veronika. Schilcher. Nicole. Ladurner. Angela. Heiss. Elke H.. Stangl. Herbert. Bauer. Rudolf. Dirsch. Verena M.. Atanasov. Atanas G.. Frontiers in Pharmacology. 8. 596. 28919859. 5585181. .
  8. Christensen, L. P. . Aliphatic C17-Polyacetylenes of the Falcarinol Type as Potential Health Promoting Compounds in Food Plants of the Apiaceae Family . Recent Patents on Food, Nutrition & Agriculture . 2011 . 3 . 1 . 64–77 . 10.2174/2212798411103010064 . 21114468 .
  9. J. Ethnopharmacol. . 2010 . 132 . 1 . 280–285 . 10.1016/j.jep.2010.08.026 . 20723598 . Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq.) . Sun . S . Du . GJ . Qi . LW . Williams . S . Wang . CZ . Yuan . CS . 3050531.

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