Extended-spectrum penicillin explained

The extended-spectrum penicillins are a group of antibiotics that have the widest antibacterial spectrum of all penicillins.^[1] Some sources identify them with antipseudomonal penicillins,^[2] others consider these types to be distinct.^[3] This group includes the carboxypenicillins and the ureidopenicillins. Aminopenicillins, in contrast, do not have activity against Pseudomonas species, as their positively charged amino group does not hinder degradation by bacterially produced beta-lactamases.^[4]

Products

• Ureidopenicillins
  • Azlocillin
  • Mezlocillin
  • Piperacillin
• Carboxypenicillins
  • Ticarcillin (generally in the combination ticarcillin/clavulanic acid)
  • Carbenicillin
• Mecillinam

See also

• Pseudomonas aeruginosa § Treatment

Notes and References

1. Comprehensive Pharmacy Review, Leon Shargel, 6th edition, p917
2. Book: Kester . Mark . Karpa . Kelly Dowhower . Vrana . Kent E. . Kent Vrana . Elsevier's Integrated Review Pharmacology E-Book . 2011 . Elsevier Health Sciences . 9781455727032 .
3. Book: Clark . Michelle A. . Harvey . Richard A. . Finkel . Richard . Rey . Jose A. . Whalen . Karen . Pharmacology . 2011 . Lippincott Williams & Wilkins . 9781451113143 . 383 .
4. Book: Golan, David E.. Principles of Pharmacology. 15 December 2011. Lippincott Williams & Wilkins. 978-1608312702. 610. 2.