Exoribonuclease H Explained

Exoribonuclease H
Ec Number:	3.1.13.2

Exoribonuclease H is an enzyme.^[1] This enzyme catalyses the following chemical reaction

3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid

This is a secondary reaction to the RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end performed by EC 3.1.26.13 (retroviral ribonuclease H).

Notes and References

1. Schatz O, Mous J, Le Grice SF . HIV-1 RT-associated ribonuclease H displays both endonuclease and 3'----5' exonuclease activity . The EMBO Journal . 9 . 4 . 1171–6 . April 1990 . 1691093 . 551793 .