Exonuclease VII explained

Symbol:	Exonuc_VII_L
Exonuclease VII, large subunit
Pfam:	PF02601
Interpro:	IPR020579

Symbol:	Exonuc_VII_S
Exonuclease VII small subunit
Pfam:	PF02609
Interpro:	IPR003761

The enzyme exodeoxyribonuclease VII (EC 3.1.11.6, Escherichia coli exonuclease VII, E. coli exonuclease VII, endodeoxyribonuclease VII, exodeoxyribonuclease VII) is a bacterial exonuclease enzyme.^{[1] [2]} It is composed of two nonidentical subunits; one large subunit and 4 small ones.^[3] that catalyses exonucleolytic cleavage in either 5′- to 3′- or 3′- to 5′-direction to yield nucleoside 5′-phosphates. The large subunit also contains an N-terminal OB-fold domain that binds to nucleic acids.

Notes and References

1. Ribonuclease VII of Escherichia coli . Chase, J.W. . Richardson, C.C. . J. Biol. Chem. . 1974 . 249 . 4545–4552 . 4602029 . 14. 10.1016/S0021-9258(19)42453-8 . free .
2. Exonuclease VII of Escherichia coli . Chase, J.W. . Richardson, C.C. . J. Biol. Chem. . 1974 . 249 . 4553–4561 . 4602030 . 14. 10.1016/S0021-9258(19)42454-X . free .
3. Vales LD, Rabin BA, Chase JW . Subunit structure of Escherichia coli exonuclease VII . J. Biol. Chem. . 257 . 15 . 8799–805 . August 1982 . 10.1016/S0021-9258(18)34201-7 . 6284744 . free .