Eurycomanone Explained

Eurycomanone is a chemical compound that has been isolated from Eurycoma longifolia, also known as the longjack plant or tongkat ali.^[1] Eurycomanone is distributed throughout the plant, with the highest concentration in leaves. Researchers measured 6.0568 μg/mL in leaves, and only 0.3533 μg/mL in roots. ^[2]

Mechanism of action

Eurycomanone is thought to be central to the sex-hormone increasing effects of Eurycoma longifolia supplementation. In vitro, eurycomanone has been shown to enhance testosterone steroidogenesis through its inhibitory effects on aromatase, presumably causing testosterone production to increase to restore downstream estrogen homeostasis.

As of November 2022, there are no studies investigating the effects of isolated Eurycomanone in human subjects. However, studies investigating the effects supplementation with Eurycoma longifolia in human subjects have observed increases in free and total testosterone, with some studies showing increases or no changes in estradiol, luteinizing hormone, sex binding hormone globulin and follicle-stimulating hormone in both healthy and hypogonadism-affected men.^{[3] [4] [5]}

Notes and References

1. Low. Bin-Seng. Choi. Sy-Bing. Abdul Wahab. Habibah. Kumar Das. Prashanta. Chan. Kit-Lam. August 2013. Eurycomanone, the major quassinoid in Eurycoma longifolia root extract increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis. Journal of Ethnopharmacology. 149. 1. 201–207. 10.1016/j.jep.2013.06.023. 23810842.
2. Jusoh. Samsiah. Ghani. Rosnani Abd.. Kadir. Wan Rasidah W Ab. Ishak. Mohamad Fakhri. October 2015. Phytochemical Assessment of Multi-Locational Tongkat Ali (Eurycoma longifolia) in Peninsular Malaysia. Jurnal Teknologi. 77. 3. 10.11113/jt.v77.6011. free.
3. Chan . Kai Quin . Stewart . Claire . Chester . Neil . Hamzah . Sareena H. . Yusof . Ashril . May 2021 . The effect of Eurycoma Longifolia on the regulation of reproductive hormones in young males . Andrologia . 53 . 4 . e14001 . 10.1111/and.14001 . 1439-0272 . 33559971. 231868035 . free .
4. Leisegang . Kristian . Finelli . Renata . Sikka . Suresh C. . Panner Selvam . Manesh Kumar . 2022-08-04 . Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials . Medicina (Kaunas, Lithuania) . 58 . 8 . 1047 . 10.3390/medicina58081047 . 1648-9144 . 9415500 . 36013514. free .
5. Talbott . Shawn M . Talbott . Julie A . George . Annie . Pugh . Mike . 2013-05-26 . Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects . Journal of the International Society of Sports Nutrition . 10 . 1 . 28 . 10.1186/1550-2783-10-28 . 1550-2783 . 3669033 . 23705671 . free .