Eugenol synthase explained

Eugenol synthase
Ec Number:	1.1.1.318

Eugenol synthase (LtCES1, EGS1, EGS2) is an enzyme with systematic name eugenol:NADP⁺ oxidoreductase (coniferyl ester reducing).^{[1] [2] [3] [4] [5] [6]} This enzyme catalyses the following chemical reaction: eugenol + a carboxylate + NADP⁺

\rightleftharpoons a coniferyl ester + NADPH + H⁺

The enzyme acts in the reverse direction.

Notes and References

1. Koeduka T, Fridman E, Gang DR, Vassão DG, Jackson BL, Kish CM, Orlova I, Spassova SM, Lewis NG, Noel JP, Baiga TJ, Dudareva N, Pichersky E . Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol ester . Proceedings of the National Academy of Sciences of the United States of America . 103 . 26 . 10128–33 . June 2006 . 16782809 . 1502517 . 10.1073/pnas.0603732103 . free .
2. Vassão DG, Kim SJ, Milhollan JK, Eichinger D, Davin LB, Lewis NG . A pinoresinol-lariciresinol reductase homologue from the creosote bush (Larrea tridentata) catalyzes the efficient in vitro conversion of p-coumaryl/coniferyl alcohol esters into the allylphenols chavicol/eugenol, but not the propenylphenols p-anol/isoeugenol . Archives of Biochemistry and Biophysics . 465 . 1 . 209–18 . September 2007 . 17624297 . 10.1016/j.abb.2007.06.002 .
3. Louie GV, Baiga TJ, Bowman ME, Koeduka T, Taylor JH, Spassova SM, Pichersky E, Noel JP . Structure and reaction mechanism of basil eugenol synthase . PLOS ONE . 2 . 10 . e993 . October 2007 . 17912370 . 1991597 . 10.1371/journal.pone.0000993 . 2007PLoSO...2..993L . free .
4. Koeduka T, Louie GV, Orlova I, Kish CM, Ibdah M, Wilkerson CG, Bowman ME, Baiga TJ, Noel JP, Dudareva N, Pichersky E . The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages . The Plant Journal . 54 . 3 . 362–74 . May 2008 . 18208524 . 2741023 . 10.1111/j.1365-313X.2008.03412.x .
5. Koeduka T, Baiga TJ, Noel JP, Pichersky E . Biosynthesis of t-anethole in anise: characterization of t-anol/isoeugenol synthase and an O-methyltransferase specific for a C7-C8 propenyl side chain . Plant Physiology . 149 . 1 . 384–94 . January 2009 . 18987218 . 2613694 . 10.1104/pp.108.128066 .
6. Gupta AK, Schauvinhold I, Pichersky E, Schiestl FP . Eugenol synthase genes in floral scent variation in Gymnadenia species . Functional & Integrative Genomics . 14 . 4 . 779–88 . December 2014 . 25239559 . 10.1007/s10142-014-0397-9 . 20.500.11850/91540 . 17207240 . free .