Etonitazepipne Explained

Drug Name:	Etonitazepipne
Legal Uk:	PSA
Legal De:	NpSG
C:	23
H:	28
N:	4
O:	3
Iupac Name:	2-[(4-Ethoxyphenyl)methyl]-5-nitro-1-(2-piperidin-1-ylethyl)benzimidazole
Cas Number:	734496-28-7
Unii:	7AF6EZ8PMY
Pubchem:	162623834
Smiles:	CCOC1=CC=C(C=C1)CC2=NC3=C(N2CCN4CCCCC4)C=CC(=C3)[N+](=O)[O-]
Stdinchi:	1S/C23H28N4O3/c1-2-30-20-9-6-18(7-10-20)16-23-24-21-17-19(27(28)29)8-11-22(21)26(23)15-14-25-12-4-3-5-13-25/h6-11,17H,2-5,12-16H2,1H3
Stdinchikey:	UMGXRAISFRUVKD-UHFFFAOYSA-N

Etonitazepipne (N-piperidino etonitazene) is a benzimidazole derivative with opioid effects around 100 times more potent than morphine,^{[1] [2]} which has been sold over the internet as a designer drug.^{[3] [4] [5] [6]}

See also

• Etazene
• Etonitazepyne
• Isotonitazene
• Metonitazene
• Protonitazepyne
• List of benzimidazole opioids

Notes and References

1. Hunger A, Kebrle J, Rossi A, Hoffmann K . Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-benzyl-nitro-benzimidazolen. . Helvetica Chimica Acta . 1960 . 43 . 4 . 1032–1046 . 10.1002/hlca.19600430412 .
2. Berardinelli D, Taoussi O, Carlier J, Tini A, Zaami S, Sundermann T, Busardò FP, Auwärter V . In vitro, in vivo metabolism and quantification of the novel synthetic opioid N-piperidinyl etonitazene (etonitazepipne) . Clinical Chemistry and Laboratory Medicine . 62 . 8 . 1580–1590 . July 2024 . 38311816 . 10.1515/cclm-2023-1360 .
3. Alert from NDEWS Web Monitoring Team: Increase in discussion of etonitazepipne . National Drug Early Warning System. Weekly Briefing . 43 . 9 July 2021 .
4. Web site: Warnings Etonitazepipne . Knowdrugs.app . 9 August 2021 .
5. Vandeputte MM, Verougstraete N, Walther D, Glatfelter GC, Malfliet J, Baumann MH, Verstraete AG, Stove CP . First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass . Archives of Toxicology . 96 . 6 . 1865–1880 . June 2022 . 35449307 . 10.1007/s00204-022-03294-2 . 253718213 . 1854/LU-8751259 . free .
6. Calello DP, Aldy K, Jefri M, Nguyen TT, Krotulski A, Logan B, Brent J, Wax P, Walton S, Manini AF . Identification of a novel opioid, N-piperidinyl etonitazene (etonitazepipne), in patients with suspected opioid overdose . Clinical Toxicology . 60 . 9 . 1067–1069 . September 2022 . 35708103 . 9815205 . 10.1080/15563650.2022.2084406 .