Etodesnitazene Explained

Etodesnitazene (Desnitroetonitazene, Etazen, Etazene, Etazone) is a benzimidazole derived opioid analgesic drug, which was originally developed in the late 1950s alongside etonitazene and a range of related derivatives.^[1] It is many times less potent than etonitazene itself, but still 70x more potent than morphine in animal studies. Corresponding analogues where the N,N-diethyl group is replaced by piperidine or pyrrolidine rings also retain significant activity (10x and 20x morphine respectively).^[2] Etodesnitazene has been sold as a designer drug,^[3] first being identified in both Poland and Finland in March 2020.^{[4] [5]}

See also

• Brorphine
• Etonitazepyne
• Etoacetazene
• Etocyanazene
• Etomethazene
• Isotonitazene
• Metonitazene
• Metodesnitazene
• MCHB-1
• List of benzimidazole opioids

Notes and References

1. Ujváry I, Christie R, Evans-Brown M, Gallegos A, Jorge R, de Morais J, Sedefov R . DARK Classics in Chemical Neuroscience: Etonitazene and Related Benzimidazoles . ACS Chemical Neuroscience . 12 . 7 . 1072–1092 . April 2021 . 33760580 . 10.1021/acschemneuro.1c00037 . 232356192 .
2. Hunger A, Kebrle J, Rossi A, Hoffmann K . Benzimidazol-Derivate und verwandte Heterocyclen. II. Synthese von 1-Aminoalkyl-2-benzyl-benzimidazolen. . German . Helvetica Chimica Acta . 1960 . 43 . 3 . 800–809 . 10.1002/hlca.19600430323 .
3. Siczek M, Zawadzki M, Siczek M, Chłopaś-Konowałek A, Szpot P. Etazene (N,N-diethyl-2--ethan-1-amine (dihydrochloride)): a novel benzimidazole opioid NPS identified in seized material: crystal structure and spectroscopic characterization. Forensic Toxicology. 2020. 1860-8973. 10.1007/s11419-020-00552-9 . free.
4. Siczek M, Zawadzki M, Siczek M, Chłopaś-Konowałek A, Szpot P . January 2021 . Etazene (N,N-diethyl-2--ethan-1-amine (dihydrochloride)): a novel benzimidazole opioid NPS identified in seized material: crystal structure and spectroscopic characterization . Forensic Toxicology . en . 39 . 1 . 146–155 . 10.1007/s11419-020-00552-9 . 1860-8965. free .
5. Web site: EU Early Warning System Situation Report. Situation report 1 . June 2020 . European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) .