Etilefrine pivalate explained

Cas Number:85750-39-6
Pubchem:157211
Chemspiderid:138362
Unii:3RLD929C4S
Chebi:134737
Chembl:2105571
Synonyms:Etilephrine pivalate; Ethylnorphenylephrine pivalate; Pivalyletilefrine; 3,β-Dihydroxy-N-ethylphenethylamine 3-pivalate
Iupac Name:[3-[2-(ethylamino)-1-hydroxyethyl]phenyl] 2,2-dimethylpropanoate
C:15
H:23
N:1
O:3
Smiles:CCNCC(C1=CC(=CC=C1)OC(=O)C(C)(C)C)O
Stdinchi:1S/C15H23NO3/c1-5-16-10-13(17)11-7-6-8-12(9-11)19-14(18)15(2,3)4/h6-9,13,16-17H,5,10H2,1-4H3
Stdinchikey:DRMHNJGOEAYOIZ-UHFFFAOYSA-N

Etilefrine pivalate ; developmental code name K-30052) is a sympathomimetic agent which was never marketed.[1] [2] It is the 3-pivalate ester of etilefrine (ethylnorphenylephrine) and has much greater lipophilicity than etilefrine.[3] Some related compounds include pivenfrine (phenylephrine pivalate) and dipivefrine (epinephrine dipivalate), which were developed as mydriatic agents.

Notes and References

  1. Book: Elks J . A-00272: 2-Amino-1-(3-hydroxyphenyl)ethanol: Etilefrine pivalate . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer US . 2014 . 978-1-4757-2085-3 . https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA61 . 1 September 2024 . 61,455,1001.
  2. Book: Morton IK, Hall JM . Etilefrine . Concise Dictionary of Pharmacological Agents: Properties and Synonyms . Springer Netherlands . 2012 . 978-94-011-4439-1 . https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA116 . 2024-09-01 . 116.
  3. Web site: Etilefrine pivalate . PubChem . U.S. National Library of Medicine . 1 September 2024.