Ethenzamide Explained

Ethenzamide (2-ethoxybenzamide) is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains.^{[1] [2]} It is also an ingredient in numerous cold medications and many prescription analgesics. It is used as an over-the-counter drug in Japan, often in combination with caffeine and acetaminophen, where it is marketed for uses including toothache, menstrual cramps, headache, and fever.^[3]

It is metabolized in vivo into salicylamide.^[4]

Notes and References

1. Darias V, Bravo L, Abdallah SS, Sánchez Mateo CC, Expósito-Orta MA, Lissavetsky J, Manzanares J . Synthesis and preliminary pharmacological study of thiophene analogues of the antipyretic and analgesic agent ethenzamide . Archiv der Pharmazie . 325 . 2 . 83–7 . February 1992 . 1605721 . 10.1002/ardp.19923250206 . 28098596 .
2. Wang PJ, Guo HR . 10.1007/s10194-004-0065-x . Frequent analgesics consumption in migraineurs: Comparison between chronic and episodic migraineurs . . 5 . 30–35 . 2004 . 1 . 3452147 .
3. Web site: OTC Pain Relief Medicine in Japan . Life Abroad . March 22, 2021.
4. Web site: ja . エテンザミド . Ethenzamide . March 22, 2021.