Profenamine Explained

Profenamine (INN; also known as ethopropazine (BAN); solde under the trade name Parsidol and others) is a phenothiazine derivative used as an antiparkinsonian agent[1] [2] that has anticholinergic, antihistamine, and antiadrenergic actions. It is also used in the alleviation of the extrapyramidal syndrome induced by drugs such as other phenothiazine compounds, but, like other compounds with antimuscarinic properties, is of no value against tardive dyskinesia.

Synthesis

For promoting bone growth:[3]

The alkylation between phenothiazine [92-84-2] (1) and 1-Diethylamino-2-chloropropane [761-21-7] (2) in the presence of Sodium amide gives ethopropazine (3).

Notes and References

  1. Web site: Prefenamine . drugs.com.
  2. Book: Morton IK, Hall JM . Ethopropazine . https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA115 . 115 . Concise Dictionary of Pharmacological Agents: Properties and Synonyms . 1999 . Springer Netherlands . Dordrecht . 9789401144391.
  3. Debra Ellies, William Rosenberg, (2010 to Osteogenex Inc.).