Etanidazole Explained

Etanidazole is a nitroimidazole drug that was investigated in clinical trials for its radiosensitizing properties in cancer treatment. Administration of etanidazole results in a decrease of glutathione concentration and inhibits glutathione S-transferase.^{[1] [2]} The result is that tissues become more sensitive to the ionizing radiation.^[3]

See also

• 18F-EF5, a related nitroimidazole
• Misonidazole

Notes and References

1. http://www.cancer.gov/templates/drugdictionary.aspx?CdrID=39446 Definition of etanidazole
2. . Accessed 27 April 2021.
3. Hypoxia and etanidazole alter radiation-induced apoptosis in HL60 cells but not in MOLT-4 cells. 2002. 10.1080/09553000110105695. Inanami. O.. Sugihara. K.. Okui. T.. Hayashi. M.. Tsujitani. M.. Kuwabara. M.. International Journal of Radiation Biology. 78. 4. 267–274. 12020438. 37923448.