Etanautine Explained

Etanautine, also known as diphenhydramine monoacefyllinate, is an anticholinergic used as an antiparkinsonian agent. It is a 1:1 salt of diphenhydramine with acefylline, similar to the diphenhydramine/8-chlorotheophylline combination product dimenhydrinate.[1]

As with dimenhydrinate, the stimulant effect of the etanautine counteracts the sedative effect from the diphenhydramine, resulting in an improved therapeutic profile.[2]

The 1:2 salt diphenhydramine diacefylline (with two molecules of acefylline to each molecule of diphenhydramine) is also used in medicine, under the brand name Nautamine.[3]

Notes and References

  1. Book: Sicari V, Zabbo CP . Diphenhydramine . 2022 . http://www.ncbi.nlm.nih.gov/books/NBK526010/ . StatPearls . Treasure Island (FL) . StatPearls Publishing . 30252266 . 2022-11-02 .
  2. Gonzalez F . Diphenhydramine may be useful as a palliative treatment for patients dying with Parkinson's disease and tremors: a case report and discussion . The American Journal of Hospice & Palliative Care . 26 . 6 . 474–475 . August 21, 2009 . 19700649 . 10.1177/1049909109338937 . 206633832 .
  3. Web site: Diphenhydramine Dosage Guide + Max Dose, Adjustments . 2022-11-02 . Drugs.com . en.

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