Estrone benzoate explained

Estrone benzoate, or estrone 3-benzoate, is a synthetic estrogen and estrogen ester – specifically, the C3 benzoate ester of estrone – which was first reported in 1932 and was never marketed.^{[1] [2] [3] [4]} It led to the development in 1933 of the more active estradiol benzoate, the first estradiol ester to be introduced for medical use.^{[5] [6] [7] [8]}

See also

• List of estrogen esters § Estrone esters

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 900–.
2. Book: Labhart A . Clinical Endocrinology: Theory and Practice. 6 December 2012. Springer Science & Business Media. 978-3-642-96158-8. 512–.
3. Parkes AS . Effective Absorption of Hormones . British Medical Journal . 1 . 4024 . 371–373 . February 1938 . 20781252 . 2085798 . 10.1136/bmj.1.4024.371 .
4. Butenandt A, Störmer I . Über isomere Follikelhormone. Untersuchungen über das weibliche Sexualhormon, 7. Mitteilung.. About isomeric follicle hormones. Studies on the female sex hormone, 7th communication.. Hoppe-Seyler's Zeitschrift für physiologische Chemie. 208. 4. 1932. 129–148. 0018-4888. 10.1515/bchm2.1932.208.4.129.
5. Book: Oettel M, Schillinger E . Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. 6 December 2012. Springer Science & Business Media. 978-3-642-58616-3. 8–.
6. Miescher K, Scholz C, Tschopp E . The activation of female sex hormones: Mono-esters of alpha-oestradiol . The Biochemical Journal . 32 . 8 . 1273–1280 . August 1938 . 16746750 . 1264184 . 10.1042/bj0321273b .
7. Book: Raviña E, Kubinyi H . The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs . 20 May 2012 . 16 May 2011 . John Wiley & Sons . 978-3-527-32669-3 . 175.
8. Folley SJ . The effect of oestrogenic hormones on lactation and on the phosphatase of the blood and milk of the lactating cow . The Biochemical Journal . 30 . 12 . 2262–2272 . December 1936 . 16746289 . 1263335 . 10.1042/bj0302262 .