Estrogen-related receptor beta explained

Estrogen-related receptor beta (ERR-β), also known as ESRRB or NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (Estrogen Related Receptor Beta) gene .^[1]

Function

ESRRB has been shown to be vital for the transition between a naïve pluripotent and primed pluripotent state in mammalian cells, and NANOG controls the expression of ESRRB in this scenario.^[2]

References

Further reading

• Giguère V, Yang N, Segui P, Evans RM . Identification of a new class of steroid hormone receptors . Nature . 331 . 6151 . 91–94 . January 1988 . 3267207 . 10.1038/331091a0 . 4275394 . 1988Natur.331...91G .
• Sladek R, Beatty B, Squire J, Copeland NG, Gilbert DJ, Jenkins NA, Giguère V . Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene . Genomics . 45 . 2 . 320–326 . October 1997 . 9344655 . 10.1006/geno.1997.4939 .
• Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjöld M, Gustafsson JA . 6 . Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern . The Journal of Clinical Endocrinology and Metabolism . 82 . 12 . 4258–4265 . December 1997 . 9398750 . 10.1210/jcem.82.12.4470 . free .
• Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q, Caskey CT . 6 . Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR . Gene . 228 . 1–2 . 101–109 . March 1999 . 10072763 . 10.1016/S0378-1119(98)00619-2 .
• Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM . Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2 . Molecular Endocrinology . 13 . 12 . 2151–2162 . December 1999 . 10598588 . 10.1210/mend.13.12.0381 . free .
• Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE . Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition . Journal of Molecular Biology . 327 . 4 . 819–832 . April 2003 . 12654265 . 10.1016/S0022-2836(03)00183-9 . Jane Dyson .
• Kruijver FP, Balesar R, Espila AM, Unmehopa UA, Swaab DF . Estrogen-receptor-beta distribution in the human hypothalamus: similarities and differences with ER alpha distribution . The Journal of Comparative Neurology . 466 . 2 . 251–277 . November 2003 . 14528452 . 10.1002/cne.10899 . 86143014 .
• Stossi F, Barnett DH, Frasor J, Komm B, Lyttle CR, Katzenellenbogen BS . Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors . Endocrinology . 145 . 7 . 3473–3486 . July 2004 . 15033914 . 10.1210/en.2003-1682 . free .
• Verdier-Sevrain S, Yaar M, Cantatore J, Traish A, Gilchrest BA . Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism . FASEB Journal . 18 . 11 . 1252–1254 . August 2004 . 15208259 . 10.1096/fj.03-1088fje . free . 20159723 .
• Smith LH, Coats SR, Qin H, Petrie MS, Covington JW, Su M, Eren M, Vaughan DE . 6 . Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells . Circulation Research . 95 . 3 . 269–275 . August 2004 . 15217907 . 10.1161/01.RES.0000136521.70093.f1 . 43765339 .
• Liu PY, Christian RC, Ruan M, Miller VM, Fitzpatrick LA . Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease . The Journal of Clinical Endocrinology and Metabolism . 90 . 2 . 1041–1046 . February 2005 . 15536156 . 10.1210/jc.2004-1211 . free .
• Cheung CP, Yu S, Wong KB, Chan LW, Lai FM, Wang X, Suetsugi M, Chen S, Chan FL . 6 . Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues . The Journal of Clinical Endocrinology and Metabolism . 90 . 3 . 1830–1844 . March 2005 . 15598686 . 10.1210/jc.2004-1421 . free .
• Zhou W, Liu Z, Wu J, Liu JH, Hyder SM, Antoniou E, Lubahn DB . Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta . The Journal of Clinical Endocrinology and Metabolism . 91 . 2 . 569–579 . February 2006 . 16332939 . 10.1210/jc.2004-1957 . free .

Notes and References

1. Web site: Entrez Gene: ESRRB estrogen-related receptor beta.
2. Festuccia N, Halbritter F, Corsinotti A, Gagliardi A, Colby D, Tomlinson SR, Chambers I . Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation . The EMBO Journal . 37 . 21 . e95476 . November 2018 . 30275266 . 6213284 . 10.15252/embj.201695476 .