Estradiol phosphate explained

Estradiol phosphate, or estradiol 17β-phosphate, also known as estra-1,3,5(10)-triene-3,17β-diol 17β-(dihydrogen phosphate), is an estrogen which was never marketed. It is an estrogen ester, specifically an ester of estradiol with phosphoric acid, and acts as a prodrug of estradiol in the body.^[1] It is rapidly cleaved by phosphatase enzymes into estradiol upon administration. Estradiol phosphate is contained within the chemical structures of two other estradiol esters, polyestradiol phosphate (a polymer of estradiol phosphate) and estramustine phosphate (estradiol 3-normustine 17β-phosphate), both of which have been marketed for the treatment of prostate cancer.^{[2] [3]}

See also

• List of estrogen esters § Estradiol esters

Notes and References

1. Gunnarsson PO, Norlén BJ . Clinical pharmacology of polyestradiol phosphate . The Prostate . 13 . 4 . 299–304 . 1988 . 3217277 . 10.1002/pros.2990130405 . 33063805 .
2. Book: Abbou CC, Beaumont V, Chopin D, Deburge JP, Beaumont JL, Auvert J . Treatment of prostatic cancer with diethylstilboestrol and detection of the vascular risk . Smith PH . Cancer of the Prostate and Kidney. https://books.google.com/books?id=gtAFCAAAQBAJ&pg=PA359. 29 June 2013. Springer Science & Business Media. 978-1-4684-4349-3. 359–.
3. Book: Cavalli F, Kaye SB, Hansen HH, Armitage JO, Piccart-Gebhart M . Appendix: Endocrine Therapies . Textbook of Medical Oncology . Fourth . https://books.google.com/books?id=WdDKBQAAQBAJ&pg=PA442 . 12 September 2009. CRC Press. 978-0-203-09289-7. 442–.