Estradiol 17β-acetate explained

Estradiol 17β-acetate is an estrogen and an estrogen ester—specifically, the C17β acetate ester of estradiol—which was never marketed.[1] [2] [3] It is the C17β positional isomer of the better-known and clinically used estradiol ester estradiol acetate (estradiol 3-acetate; Femtrace).

See also

Notes and References

  1. Junkmann K, Witzel H . Chemie und Pharmakologie von Steroidhormon-Estern . Chemistry and pharmacology of steroid hormone esters . de . Z Vitam Horm Fermentforsch . 9 . 1–2 . 97–143 contd . 1957 . 13531579 .
  2. Janocko L, Larner JM, Hochberg RB . The interaction of C-17 esters of estradiol with the estrogen receptor . Endocrinology . 114 . 4 . 1180–6 . April 1984 . 6705734 . 10.1210/endo-114-4-1180 .
  3. Mu Y, Peng S, Zhang A, Wang L . Role of pocket flexibility in the modulation of estrogen receptor alpha by key residue arginine 394 . Environ. Toxicol. Chem. . 30 . 2 . 330–6 . February 2011 . 21038436 . 10.1002/etc.389 . 22116062 .

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