| Type: | combo |
| Component1: | Esafoxolaner |
| Class1: | aryl isoxazoline |
| Component2: | Eprinomectin |
| Class2: | avermectin anthelmintic |
| Component3: | Praziquantel |
| Class3: | pyrazinoisoquinoline anthelmintic |
| Tradename: | Nexgard Combo |
| Dailymedid: | Esafoxolaner, eprinomectin, and praziquantel |
| Routes Of Administration: | Topical |
| Atc Supplemental: | , |
| Legal Ca: | Rx-only |
| Legal Ca Comment: | [1] [2] |
| Legal Us: | Rx-only |
| Legal Us Comment: | [3] |
Esafoxolaner/eprinomectin/praziquantel, sold under the brand name Nexgard Combo, is a fixed-dose combination medication used for the treatment and control of flea infestations, ticks, ear mites, and infections caused by tapeworms and Toxocara cati in cats.[4] It is also used for the prevention of heartworm disease Dirofilaria immitis. It contains esafoxolaner, an aryl isoxazoline; eprinomectin, an avermectin anthelmintic; and praziquantel, a pyrazinoisoquinoline anthelmintic.
In the United States, esafoxolaner/eprinomectin/praziquantel is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (fourth stage larval and adult Toxocara cati), hookworm (fourth stage larval and adult Ancylostoma tubaeforme; adult Ancylostoma braziliense), and tapeworm (Dipylidium caninum) infections. It kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations and the treatment and control of Ixodes scapularis (black-legged tick) and Amblyomma americanum (lone star tick) infestations for one month in cats and kittens eight weeks of age and older, and weighing 1.8lb or greater.[5] [6]