Ergosterol peroxide explained

Ergosterol peroxide (5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol) is a steroid derivative. It has been isolated from a variety of fungi, yeast, lichens and sponges,^{[1] [2] [3] [4] [5]} and has been reported to exhibit immunosuppressive,^[6] anti-inflammatory,^[7] antiviral,^[8] trypanocidal ^[9] and antitumor activities in vitro.^{[10] [11]}

Notes and References

1. Lobo AM, Abreu PM, Prabhakar S, Godhino LS, Jones R, Rzepa HS, Williams DJ . 1988 . Triterpenoids of the fungus Pisolithus tinctorius . Phytochemistry . 27 . 11. 3569–74 . 10.1016/0031-9422(88)80770-2. 1988PChem..27.3569L .
2. Jimenez C, Quinoa E, Rignera R, Vilalta R, Quintella JM . 1989 . The dietary origin of epidioxy steroids in Actinia equina. A carbon14 incorporation experiment . Journal of Natural Products. 52 . 3. 619–22 . 10.1021/np50063a023.
3. Kahols K, Kangas L, Hiltunen R . 1989 . Ergosterol peroxide, an active compound from Inonotus radiatus. Planta Medica. 55 . 4. 389–90 . 10.1055/s-2006-962036. 2813575.
4. Tchouankeu JC, Nyasse B, Tsamo E, Sondengam B, Morin C . 1992 . An ergostane derivative from the bark of Entandrophragma utile . Phytochemistry. 31. 2. 704–705 . 10.1016/0031-9422(92)90067-Z. 1992PChem..31..704T .
5. Fujimoto H, Nakayama Y, Yamazaki M . 1994 . Isolation and characterization of immunosuppressive components of three mushrooms, Pisolithus tinctorius, Microporus flabelliformis and Lenzites betulina . Chem. Pharm. Bull. . 42 . 3. 694–97 . 10.1248/cpb.42.694. 8004718 . free .
6. Yasukawa K, Akihisa T, Kanno H, Kaminaga T, Izumida M, Sakoh T, Tamura T, Takido M . 1996 . Inhibitory effects of sterols isolated from Chlorella vulgaris on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and tumor promotion in mouse skin . Biological and Pharmaceutical Bulletin. 19 . 4. 573–576 . 10.1248/bpb.19.573. 8860961. free.
7. Lindequist U, Lesnau A, Teuscher E, Pilgrim H . 1989 . Antiviral activity of ergosterol peroxide . Pharmazie. 44 . 8. 579–80 . 2594833.
8. Nakanishi T, Murata H, Inatomi Y, Inada A, Murata J, Lang FA, Yamasaki K, Nakano M, Kawahata T, Mori H, Otake T . 1998 . Screening of anti-HIV-1 activity of North American plants. Anti-HIV-1 activities of plant extracts, and active components of Lethalia vulpina (L.) Hue . Journal of Natural Medicines . 52 . 521–26 .
9. Trypanocidal Activity of Ergosterol Peroxide from Pleurotus ostreatus. Phytotherapy Research. 2012-06-01. 1099-1573. 938–943. 26. 6. 10.1002/ptr.3653. 22083593. en. Angel. Ramos-Ligonio. Aracely. López-Monteon. Ángel. Trigos. 1858275.
10. Bok JW, Lermer L, Chilton J, Klingeman HG, Towers NG . 1999 . Antitumor sterols from the mycelia of Cordyceps sinensis . Phytochemistry . 51. 7. 891–98 . 10.1016/S0031-9422(99)00128-4. 10423860 . 1999PChem..51..891B . 10.1.1.565.2857 .
11. Nam KS, Jo YS, Kim YH, Hyun JW, Kim HW . 2001 . Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipes . Life Sciences . 69 . 2 . 229–37 . 10.1016/s0024-3205(01)01125-0 . 11441913. 8970168 .