Ephedrine dehydrogenase explained

ephedrine dehydrogenase
Ec Number:	1.5.1.18
Cas Number:	73508-06-2
Go Code:	0047877

In enzymology, an ephedrine dehydrogenase is an enzyme that catalyzes the chemical reaction

(-)-ephedrine + NAD⁺

\rightleftharpoons (R)-2-methylimino-1-phenylpropan-1-ol + NADH + H⁺

Thus, the two substrates of this enzyme are (-)-ephedrine and NAD⁺, whereas its 3 products are (R)-2-methylimino-1-phenylpropan-1-ol, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (-)-ephedrine:NAD+ 2-oxidoreductase.

References

• Klamann E, Lingens F . 1980 . Degradation of (-)-ephedrine by Pseudomonas putida. Detection of (-)-ephedrine: NAD+-oxidoreductase from Arthrobacter globiformis . Z. Naturforsch. C . 35 . 80 - 7 . 7405363 . 1–2 .