Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific) explained

enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)
Ec Number:	1.3.1.10
Cas Number:	37251-09-5
Go Code:	0004319

In enzymology, an enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) is an enzyme that catalyzes the chemical reaction

acyl-[acyl-carrier-protein] + NADP⁺

\rightleftharpoons trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADPH + H⁺

Thus, the two substrates of this enzyme are acyl-[acyl-carrier-protein] and NADP⁺, whereas its 3 products are trans-2,3-dehydroacyl-[acyl-carrier-protein], NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (B-specific). Other names in common use include acyl-ACP dehydrogenase, reductase, enoyl-[acyl carrier protein] (reduced nicotinamide, adenine dinucleotide phosphate), NADPH 2-enoyl Co A reductase, enoyl acyl-carrier-protein reductase, enoyl-ACP reductase, and enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific). This enzyme participates in fatty acid biosynthesis.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .

References

• Saito K, Kawaguchi A, Okuda S, Seyama Y, Yamakawa T . 1980 . Incorporation of hydrogen atoms from deuterated water and stereospecifically deuterium-labeled nicotin amide nucleotides into fatty acids with the Escherichia coli fatty acid synthetase system . Biochim. Biophys. Acta . 618 . 202 - 13 . 6990992 . 2 . 10.1016/0005-2760(80)90026-0.
• Seyama Y, Kasama T, Yamakawa T, Kawaguchi A, Saito K . Tokyo . Origin of hydrogen atoms in the fatty acids synthesized with yeast fatty acid synthetase . J. Biochem. . 82. 1325 - 9 . 338601 . 5 . November 1977. 10.1093/oxfordjournals.jbchem.a131820 .
• Weeks G, Wakil SJ . 1968 . Studies on the mechanism of fatty acid synthesis. 18. Preparation and general properties of the enoyl acyl carrier protein reductases from Escherichia coli . J. Biol. Chem. . 243 . 1180 - 9 . 4384650 . 6 .