Enoyl-(acyl-carrier-protein) reductase (NADPH, A-specific) explained

enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific)
Ec Number:	1.3.1.39
Go Code:	0047117

In enzymology, an enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) is an enzyme that catalyzes the chemical reaction

acyl-[acyl-carrier-protein] + NADP⁺

\rightleftharpoons trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADPH + H⁺

Thus, the two substrates of this enzyme are acyl-[acyl-carrier-protein] and NADP⁺, whereas its 3 products are trans-2,3-dehydroacyl-[acyl-carrier-protein], NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (A-specific). Other names in common use include acyl-ACP dehydrogenase, enoyl-[acyl carrier protein] (reduced nicotinamide adenine, dinucleotide phosphate) reductase, NADPH 2-enoyl Co A reductase, enoyl-ACp reductase, and enoyl-[acyl-carrier-protein] reductase (NADPH2, A-specific).

References

• Dugan RE, Slakey LL, Porter JW . 1970 . Stereospecificity of the transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate to the acyl chain in the dehydrogenase-catalyzed reactions of fatty acid synthesis . J. Biol. Chem. . 245 . 6312 - 6 . 4394955 . 23 .