Endopeptidase inhibitor explained
An endopeptidase inhibitor is a drug that inhibits one or more endopeptidase enzymes. Endopeptidases are one of two types of proteases (enzymes that break down proteins and peptides), the other being exopeptidases. Endopeptidases cleave peptide bonds of non-terminal amino acids (that is, they cut proteins/peptides into two chains), whereas exopeptidases break terminal bonds, resulting in the release of a single amino acid or dipeptide from the peptide chain.
Examples of endopeptidase inhibitors
Some examples of endopeptidase inhibitors include the following:
- Neprilysin inhibitors
- Selective neprilysin inhibitors
- Non-selective neprilysin inhibitors
- Aladotril - also inhibits angiotensin converting enzyme (ACE) (an exopeptidase)
- Alatriopril - also inhibits ACE
- Daglutril - also inhibits endothelin converting enzyme (ECE) (an exopeptidase)
- Fasidotril - also inhibits ACE
- Gemopatrilat - also inhibits ACE
- Ilepatril - also inhibits ACE
- Ketalorphan - also inhibits APN, ACE, and dipeptidyl-peptidase 3 (DPP-3) (an exopeptidase)
- Omapatrilat - also inhibits ACE
- Phosphoramidon - inhibitor of neprilysin and thermolysin; also inhibits ECE
- RB-101 - also inhibits aminopeptidase N (APN) (an exopeptidase)
- Sampatrilat
- Spinorphan - also inhibits APN, ACE, and DPP-3
- Tynorphin - also inhibits APN, ACE, and DPP-3
- Trypsin inhibitors/others
- Renin inhibitors
See also
