Endo-alpha-sialidase explained

Endo-α-sialidase
Ec Number:	3.2.1.129
Cas Number:	91195-87-8

Endo-α-sialidase (endo-N-acylneuraminidase, endoneuraminidase, endo-N-acetylneuraminidase, poly(α-2,8-sialosyl) endo-N-acetylneuraminidase, poly(α-2,8-sialoside) α-2,8-sialosylhydrolase, endosialidase, endo-N) is an enzyme with systematic name polysialoside (2→8)-α-sialosylhydrolase.^{[1] [2] [3] [4] [5] [6] [7]} It catalyses the following chemical reaction:

Endohydrolysis of (2→8)-α-sialosyl linkages in oligo- or poly(sialic) acids

Notes and References

1. Finne J, Mäkelä PH . Cleavage of the polysialosyl units of brain glycoproteins by a bacteriophage endosialidase. Involvement of a long oligosaccharide segment in molecular interactions of polysialic acid . The Journal of Biological Chemistry . 260 . 2 . 1265–70 . January 1985 . 10.1016/S0021-9258(20)71238-X . 3968060 . free .
2. Hallenbeck PC, Vimr ER, Yu F, Bassler B, Troy FA . Purification and properties of a bacteriophage-induced endo-N-acetylneuraminidase specific for poly-α-2,8-sialosyl carbohydrate units . The Journal of Biological Chemistry . 262 . 8 . 3553–61 . March 1987 . 10.1016/S0021-9258(18)61387-0 . 3546309 . free .
3. Kitajima K, Inoue S, Inoue Y, Troy FA . Use of a bacteriophage-derived endo-N-acetylneuraminidase and an equine antipolysialyl antibody to characterize the polysialyl residues in salmonid fish egg polysialoglycoproteins. Substrate and immunospecificity studies . The Journal of Biological Chemistry . 263 . 34 . 18269–76 . December 1988 . 10.1016/S0021-9258(19)81355-8 . 3142874 . free .
4. Kwiatkowski B, Boschek B, Thiele H, Stirm S . Endo-N-acetylneuraminidase associated with bacteriophage particles . Journal of Virology . 43 . 2 . 697–704 . August 1982 . 10.1128/JVI.43.2.697-704.1982 . 7109038 . 256172 .
5. Pelkonen S, Pelkonen J, Finne J . Common cleavage pattern of polysialic acid by bacteriophage endosialidases of different properties and origins . Journal of Virology . 63 . 10 . 4409–16 . October 1989 . 10.1128/JVI.63.10.4409-4416.1989 . 2778882 . 251059 .
6. Tomlinson S, Taylor PW . Neuraminidase associated with coliphage E that specifically depolymerizes the Escherichia coli K1 capsular polysaccharide . Journal of Virology . 55 . 2 . 374–8 . August 1985 . 10.1128/JVI.55.2.374-378.1985 . 3894684 . 254943 .
7. Cabezas JA . Some questions and suggestions on the type references of the official nomenclature (IUB) for sialidase(s) and endosialidase . The Biochemical Journal . 278 (Pt 1) . 311–2 . August 1991 . Pt 1 . 1883340 . 1151486 . 10.1042/bj2780311 .