Endemic (epidemiology) explained

In epidemiology, an infection is said to be endemic in a specific population or populated place when that infection is constantly present, or maintained at a baseline level, without extra infections being brought into the group as a result of travel or similar means.^[1] The term describes the distribution (spread) of an infectious disease among a group of people or within a populated area.^[2] An endemic disease always has a steady, predictable number of people getting sick, but that number can be high (hyperendemic) or low (hypoendemic), and the disease can be severe or mild.^[3] ^[4] Also, a disease that is usually endemic can become epidemic.

For example, chickenpox is endemic (steady state) in the United Kingdom, but malaria is not. Every year, there are a few cases of malaria reported in the UK, but these do not lead to sustained transmission in the population due to the lack of a suitable vector (mosquitoes of the genus Anopheles). Consequently, the number of people infected by malaria in the UK is too variable to be called endemic. However, the number of people who get chickenpox in the UK varies little from year to year, so chickenpox is considered endemic in the UK.

Mathematical determination

See also: Mathematical modelling in epidemiology and Mathematical modelling of infectious disease. For an infection that relies on person-to-person transmission, to be endemic, each person who becomes infected with the disease must pass it on to one other person on average. Assuming a completely susceptible population, that means that the basic reproduction number (R₀) of the infection must equal one. In a population with some immune individuals, the basic reproduction number multiplied by the proportion of susceptible individuals in the population (S) must be one. This takes account of the probability of each individual to whom the disease may be transmitted being susceptible to it, effectively discounting the immune sector of the population. So, for a disease to be in an endemic steady state or endemic equilibrium, it holds that

R₀ x S=1

In this way, the infection neither dies out nor does the number of infected people increase exponentially but the infection is said to be in an endemic steady state. An infection that starts as an epidemic will eventually either die out (with the possibility of it resurging in a theoretically predictable cyclical manner) or reach the endemic steady state, depending on a number of factors, including the virulence of the disease and its mode of transmission.

If a disease is in an endemic steady state in a population, the relation above allows us to estimate the R₀ (an important parameter) of a particular infection. This in turn can be fed into a mathematical model for the epidemic. Based on the reproduction number, we can define the epidemic waves, such as the first wave, second wave, etc. for COVID-19 in different regions and countries.^[5]

Misuse

While it might be common to say that AIDS is endemic in some countries, meaning that it is regularly found in an area, this is a use of the word in its etymological, rather than epidemiological or ecological, form.

Some in the public wrongly assume that endemic COVID-19 means the disease severity would necessarily be mild.^[3] Endemic COVID-19 could be mild if previously acquired immunity reduces the risk of death and disability during future infections,^[6] but in itself endemicity only means that there will be a steady, predictable number of sick people.^[3]

Related terms

Categories of endemic diseases

Holoendemic

An endemic disease with an extremely high rate of infection, especially a disease that infects nearly everyone early in life, so that nearly all adults have developed some level of immunity.^[7]

Hyperendemic

An endemic disease with a high rate of infection, especially one affecting people of all ages equally.

Mesoendemic: An endemic disease with a moderate rate of infection.^[8] This term is often used to describe the prevalence of malaria in a local area, with 10 to 50% of children showing evidence of prior infection being considered a moderate level for that disease.^[9]

Categories for non-endemic diseases

Sporadic

A disease that appears occasionally, but, unlike endemic disease, is not always present at a steady and predictable level.^[11]

Outbreak

An epidemic, especially one affecting a very small area, such as the people in one town or attending a single event. The 2019–2020 measles outbreaks showed a normally endemic disease causing an epidemic outbreak, primarily among unvaccinated people.

Epidemic

A new disease that is spreading or a previously endemic disease whose infection rate is increasing significantly. Seasonal flu frequently appears as an epidemic.

Pandemic

An epidemic affecting a very large part of the world, generally multiple countries or multiple continents. Seasonal flu is sometimes a global pandemic.

Examples

This is a short, incomplete list of some infections that are usually considered endemic:

Smallpox was an endemic disease until it was eradicated through vaccination.^[12]

Etymology

The word endemic comes from the Greek: Greek, Ancient (to 1453);: ἐν,, "in, within" and Greek, Ancient (to 1453);: δῆμος,, "people".

References

Web site: Principles of Epidemiology in Public Health Practice, Third Edition An Introduction to Applied Epidemiology and Biostatistics. Centers for Disease Control and Prevention. April 19, 2018.
Book: Cook . Neal . https://books.google.com/books?id=ZsZREAAAQBAJ&dq=what+is+endemic+disease&pg=PT115 . Essentials of Pathophysiology for Nursing Practice . Shepherd . Andrea . Dunleavy . Stephanie . McCauley . Claire . 2022-04-23 . SAGE . 978-1-5297-8581-4 . 114–115 . en . Health and Disease in Society . Terms used to describe distribution include: Endemic: a condition that is generally present in a group or area, such as a cold.
Katzourakis A . COVID-19: endemic doesn't mean harmless . Nature . 601 . 7894 . 485 . January 2022 . 35075305 . 10.1038/d41586-022-00155-x . 2022Natur.601..485K . 246277859 .
Book: Ticona . Eduardo . Person Centered Medicine . Gao . George Fu . Zhou . Lei . Burgos . Marcos . 2023-04-13 . . 978-3-031-17650-0 . Mezzich . Juan E. . 465 . en . Person-Centered Infectious Diseases and Pandemics . Appleyard . James . Glare . Paul . Snaedal . Jon . Wilson . Ruth.
Zhang . Stephen X. . Marioli . Francisco Arroyo . Gao . Renfei . Wang . Senhu . 2021-09-13 . A Second Wave? What Do People Mean by COVID Waves? – A Working Definition of Epidemic Waves . Risk Management and Healthcare Policy . English . 14 . 3775–3782 . 10.2147/RMHP.S326051 . 8448159 . 34548826 . free .
Antia R, Halloran ME . October 2021 . Transition to endemicity: Understanding COVID-19 . Immunity . Review . 54 . 10 . 2172–2176 . 10.1016/j.immuni.2021.09.019 . 8461290 . 34626549.
Book: Porta . Miquel S. . A Dictionary of Epidemiology . Greenland . Sander . Hernán . Miguel . Silva . Isabel dos Santos . Last . John M. . 2014 . Oxford University Press . 978-0-19-997673-7 . 136, 139 . en.
Book: Cockerham, William C. . International Encyclopedia of Public Health . 2016-10-06 . Academic Press . 978-0-12-803708-9 . 26–27 . en.
Book: WHO Malaria Terminology, 2021 update . 2021-11-24 . World Health Organization . 978-92-4-003840-0 . 11 . en.
Book: Emch . Michael . Health and Medical Geography, Fourth Edition . Root . Elisabeth Dowling . Carrel . Margaret . 2017-02-20 . Guilford Publications . 978-1-4625-2006-0 . 22 . en.
Book: Battersby, Stephen . Clay's Handbook of Environmental Health . 2016-07-01 . Routledge . 978-1-317-38291-1 . 415–416 . en.
Katzourakis A . COVID-19: endemic doesn't mean harmless . Nature . 601 . 7894 . 485 . January 2022 . 35075305 . 10.1038/d41586-022-00155-x . 2022Natur.601..485K . 246277859 . Yes, common colds are endemic. So are Lassa fever, malaria and polio. So was smallpox, until vaccines stamped it out. [...] learning to live with endemic rotavirus, hepatitis C or measles..